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Single-Molecule Studies of the Im7 Folding Landscape

Under appropriate conditions, the four-helical Im7 (immunity protein 7) folds from an ensemble of unfolded conformers to a highly compact native state via an on-pathway intermediate. Here, we investigate the unfolded, intermediate, and native states populated during folding using diffusion single-pa...

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Detalles Bibliográficos
Autores principales: Pugh, Sara D., Gell, Christopher, Smith, D. Alastair, Radford, Sheena E., Brockwell, David J.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855442/
https://www.ncbi.nlm.nih.gov/pubmed/20211187
http://dx.doi.org/10.1016/j.jmb.2010.02.048