Cargando…
Single-Molecule Studies of the Im7 Folding Landscape
Under appropriate conditions, the four-helical Im7 (immunity protein 7) folds from an ensemble of unfolded conformers to a highly compact native state via an on-pathway intermediate. Here, we investigate the unfolded, intermediate, and native states populated during folding using diffusion single-pa...
Autores principales: | Pugh, Sara D., Gell, Christopher, Smith, D. Alastair, Radford, Sheena E., Brockwell, David J. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855442/ https://www.ncbi.nlm.nih.gov/pubmed/20211187 http://dx.doi.org/10.1016/j.jmb.2010.02.048 |
Ejemplares similares
-
Intermediates: ubiquitous species on folding energy landscapes?
por: Brockwell, David J, et al.
Publicado: (2007) -
The Mechanism of Folding of Im7 Reveals Competition between Functional and Kinetic Evolutionary Constraints
por: Friel, Claire T., et al.
Publicado: (2009) -
Outer membrane protein folding from an energy landscape perspective
por: Schiffrin, Bob, et al.
Publicado: (2017) -
Desolvation and Development of Specific Hydrophobic Core Packing during Im7 Folding
por: Bartlett, Alice I., et al.
Publicado: (2010) -
NMR Analysis of the Conformational Properties of the Trapped on-pathway Folding Intermediate of the Bacterial Immunity Protein Im7
por: Whittaker, Sara B.-M., et al.
Publicado: (2007)