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Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels

PURPOSE: Prostate cancer is rarely diagnosed in men younger than 40 years of age. At present, the available data show a low rate of cancer detection from prostate-specific antigen (PSA) screening of this group of young men. We analyzed the outcome of prostate biopsy results in patients of this age g...

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Autores principales: Yang, Jin Bak, Jeong, Byong Chang, Seo, Seong Il, Jeon, Seong Soo, Choi, Han Yong, Lee, Hyun Moo
Formato: Texto
Lenguaje:English
Publicado: The Korean Urological Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855470/
https://www.ncbi.nlm.nih.gov/pubmed/20414405
http://dx.doi.org/10.4111/kju.2010.51.1.21
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author Yang, Jin Bak
Jeong, Byong Chang
Seo, Seong Il
Jeon, Seong Soo
Choi, Han Yong
Lee, Hyun Moo
author_facet Yang, Jin Bak
Jeong, Byong Chang
Seo, Seong Il
Jeon, Seong Soo
Choi, Han Yong
Lee, Hyun Moo
author_sort Yang, Jin Bak
collection PubMed
description PURPOSE: Prostate cancer is rarely diagnosed in men younger than 40 years of age. At present, the available data show a low rate of cancer detection from prostate-specific antigen (PSA) screening of this group of young men. We analyzed the outcome of prostate biopsy results in patients of this age group with a high PSA. MATERIALS AND METHODS: Between October 1997 and August 2008, a total of 81 men less than 40 years of age were referred from the Health Care Promotion Center as the result of elevated PSA levels. Six men with prostatitis were excluded. The remaining 75 men were asymptomatic and had normal findings on the digital rectal examination (DRE) and were selected to have a transrectal ultrasound-guided prostate biopsy for suspected prostate cancer. The patients with sustained high PSA levels underwent repeat biopsies. RESULTS: The median age of the 75 men was 33 years (range, 26-40 years) and the mean PSA level was 6.57 ng/ml (range, 4.32-13.45 ng/ml). The results of the primary biopsy was 1 (1.3%) case of prostate cancer, 70 cases (93%) with benign tissue, 2 cases (2.6%) with inflammation, and 1 case each (1.3%) with high grade intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). Of the 10 men who underwent a second biopsy, all had benign findings. Three of the men who underwent a third biopsy all had benign tissue findings. CONCLUSIONS: The prostate cancer detection rate in young men less than 40 years of age with high PSA levels and normal DREs was very low. Repeat biopsy for sustained high PSA levels in young men less than 40 years of age may not be indicated.
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spelling pubmed-28554702010-04-22 Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels Yang, Jin Bak Jeong, Byong Chang Seo, Seong Il Jeon, Seong Soo Choi, Han Yong Lee, Hyun Moo Korean J Urol Original Article PURPOSE: Prostate cancer is rarely diagnosed in men younger than 40 years of age. At present, the available data show a low rate of cancer detection from prostate-specific antigen (PSA) screening of this group of young men. We analyzed the outcome of prostate biopsy results in patients of this age group with a high PSA. MATERIALS AND METHODS: Between October 1997 and August 2008, a total of 81 men less than 40 years of age were referred from the Health Care Promotion Center as the result of elevated PSA levels. Six men with prostatitis were excluded. The remaining 75 men were asymptomatic and had normal findings on the digital rectal examination (DRE) and were selected to have a transrectal ultrasound-guided prostate biopsy for suspected prostate cancer. The patients with sustained high PSA levels underwent repeat biopsies. RESULTS: The median age of the 75 men was 33 years (range, 26-40 years) and the mean PSA level was 6.57 ng/ml (range, 4.32-13.45 ng/ml). The results of the primary biopsy was 1 (1.3%) case of prostate cancer, 70 cases (93%) with benign tissue, 2 cases (2.6%) with inflammation, and 1 case each (1.3%) with high grade intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). Of the 10 men who underwent a second biopsy, all had benign findings. Three of the men who underwent a third biopsy all had benign tissue findings. CONCLUSIONS: The prostate cancer detection rate in young men less than 40 years of age with high PSA levels and normal DREs was very low. Repeat biopsy for sustained high PSA levels in young men less than 40 years of age may not be indicated. The Korean Urological Association 2010-01 2010-01-21 /pmc/articles/PMC2855470/ /pubmed/20414405 http://dx.doi.org/10.4111/kju.2010.51.1.21 Text en Copyright © The Korean Urological Association, 2010 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yang, Jin Bak
Jeong, Byong Chang
Seo, Seong Il
Jeon, Seong Soo
Choi, Han Yong
Lee, Hyun Moo
Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels
title Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels
title_full Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels
title_fullStr Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels
title_full_unstemmed Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels
title_short Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific Antigen (PSA) Levels
title_sort outcome of prostate biopsy in men younger than 40 years of age with high prostate-specific antigen (psa) levels
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855470/
https://www.ncbi.nlm.nih.gov/pubmed/20414405
http://dx.doi.org/10.4111/kju.2010.51.1.21
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