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53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

Class switch recombination (CSR) diversifies antibodies by joining highly repetitive DNA elements, which are separated by 60–200 kbp. CSR is initiated by activation-induced cytidine deaminase, an enzyme that produces multiple DNA double-strand breaks (DSBs) in switch regions. Switch regions are join...

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Detalles Bibliográficos
Autores principales:	Bothmer, Anne, Robbiani, Davide F., Feldhahn, Niklas, Gazumyan, Anna, Nussenzweig, Andre, Nussenzweig, Michel C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856023/ https://www.ncbi.nlm.nih.gov/pubmed/20368578 http://dx.doi.org/10.1084/jem.20100244

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