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IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS
BACKGROUND: The human leukocyte antigen (HLA) system in the skin coordinates the pigmentation and immune response and could be implicated in the pathogenesis of vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility complex class I molecule expressed in the extravillous cy...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856368/ https://www.ncbi.nlm.nih.gov/pubmed/20418972 http://dx.doi.org/10.4103/0019-5154.60346 |
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author | Jalel, Akrem Ridha, Aouadi Laurent, Duboisier Philippe, Moureaux Hamdaoui, M H |
author_facet | Jalel, Akrem Ridha, Aouadi Laurent, Duboisier Philippe, Moureaux Hamdaoui, M H |
author_sort | Jalel, Akrem |
collection | PubMed |
description | BACKGROUND: The human leukocyte antigen (HLA) system in the skin coordinates the pigmentation and immune response and could be implicated in the pathogenesis of vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface. It is known to protect the fetus from maternal cellular immunity. Analogically, it could be implicated in the pathogenesis of autoimmune diseases such as vitiligo. AIMS: To compare the expression of HLA-G between vitiligo patients and healthy controls. MATERIALS AND METHODS: In the present study, 22 vitiligo patients and 24 healthy controls were investigated to look for a possible correlation between HLA-G expression and this pathology. Expression of HLA-G in cutaneous biopsy specimens was investigated by immunohistochemical analysis. RESULTS: HLA-G was detected in the biopsy specimens of 3 (13%) out of 22 patients. This number was significantly higher in healthy controls 18 (75%) out of 24 as compared to vitiligo patients (P < 0.001). CONCLUSION: There is significant negative correlation between HLA-G expression and vitiligo. In our mind, upregulation of HLA-G expression in lesional skin could be local (superficial expression) or systemic (soluble HLA-G isoforms) compensation to restore normal pigmentation in lesions. |
format | Text |
id | pubmed-2856368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28563682010-04-25 IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS Jalel, Akrem Ridha, Aouadi Laurent, Duboisier Philippe, Moureaux Hamdaoui, M H Indian J Dermatol Basic Research BACKGROUND: The human leukocyte antigen (HLA) system in the skin coordinates the pigmentation and immune response and could be implicated in the pathogenesis of vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface. It is known to protect the fetus from maternal cellular immunity. Analogically, it could be implicated in the pathogenesis of autoimmune diseases such as vitiligo. AIMS: To compare the expression of HLA-G between vitiligo patients and healthy controls. MATERIALS AND METHODS: In the present study, 22 vitiligo patients and 24 healthy controls were investigated to look for a possible correlation between HLA-G expression and this pathology. Expression of HLA-G in cutaneous biopsy specimens was investigated by immunohistochemical analysis. RESULTS: HLA-G was detected in the biopsy specimens of 3 (13%) out of 22 patients. This number was significantly higher in healthy controls 18 (75%) out of 24 as compared to vitiligo patients (P < 0.001). CONCLUSION: There is significant negative correlation between HLA-G expression and vitiligo. In our mind, upregulation of HLA-G expression in lesional skin could be local (superficial expression) or systemic (soluble HLA-G isoforms) compensation to restore normal pigmentation in lesions. Medknow Publications 2010 /pmc/articles/PMC2856368/ /pubmed/20418972 http://dx.doi.org/10.4103/0019-5154.60346 Text en © Indian Journal of Dermatology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Jalel, Akrem Ridha, Aouadi Laurent, Duboisier Philippe, Moureaux Hamdaoui, M H IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS |
title | IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS |
title_full | IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS |
title_fullStr | IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS |
title_full_unstemmed | IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS |
title_short | IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS |
title_sort | impact of hla-g in the outcome of vitiligo in tunisian patients |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856368/ https://www.ncbi.nlm.nih.gov/pubmed/20418972 http://dx.doi.org/10.4103/0019-5154.60346 |
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