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IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS

BACKGROUND: The human leukocyte antigen (HLA) system in the skin coordinates the pigmentation and immune response and could be implicated in the pathogenesis of vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility complex class I molecule expressed in the extravillous cy...

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Autores principales: Jalel, Akrem, Ridha, Aouadi, Laurent, Duboisier, Philippe, Moureaux, Hamdaoui, M H
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856368/
https://www.ncbi.nlm.nih.gov/pubmed/20418972
http://dx.doi.org/10.4103/0019-5154.60346
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author Jalel, Akrem
Ridha, Aouadi
Laurent, Duboisier
Philippe, Moureaux
Hamdaoui, M H
author_facet Jalel, Akrem
Ridha, Aouadi
Laurent, Duboisier
Philippe, Moureaux
Hamdaoui, M H
author_sort Jalel, Akrem
collection PubMed
description BACKGROUND: The human leukocyte antigen (HLA) system in the skin coordinates the pigmentation and immune response and could be implicated in the pathogenesis of vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface. It is known to protect the fetus from maternal cellular immunity. Analogically, it could be implicated in the pathogenesis of autoimmune diseases such as vitiligo. AIMS: To compare the expression of HLA-G between vitiligo patients and healthy controls. MATERIALS AND METHODS: In the present study, 22 vitiligo patients and 24 healthy controls were investigated to look for a possible correlation between HLA-G expression and this pathology. Expression of HLA-G in cutaneous biopsy specimens was investigated by immunohistochemical analysis. RESULTS: HLA-G was detected in the biopsy specimens of 3 (13%) out of 22 patients. This number was significantly higher in healthy controls 18 (75%) out of 24 as compared to vitiligo patients (P < 0.001). CONCLUSION: There is significant negative correlation between HLA-G expression and vitiligo. In our mind, upregulation of HLA-G expression in lesional skin could be local (superficial expression) or systemic (soluble HLA-G isoforms) compensation to restore normal pigmentation in lesions.
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spelling pubmed-28563682010-04-25 IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS Jalel, Akrem Ridha, Aouadi Laurent, Duboisier Philippe, Moureaux Hamdaoui, M H Indian J Dermatol Basic Research BACKGROUND: The human leukocyte antigen (HLA) system in the skin coordinates the pigmentation and immune response and could be implicated in the pathogenesis of vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface. It is known to protect the fetus from maternal cellular immunity. Analogically, it could be implicated in the pathogenesis of autoimmune diseases such as vitiligo. AIMS: To compare the expression of HLA-G between vitiligo patients and healthy controls. MATERIALS AND METHODS: In the present study, 22 vitiligo patients and 24 healthy controls were investigated to look for a possible correlation between HLA-G expression and this pathology. Expression of HLA-G in cutaneous biopsy specimens was investigated by immunohistochemical analysis. RESULTS: HLA-G was detected in the biopsy specimens of 3 (13%) out of 22 patients. This number was significantly higher in healthy controls 18 (75%) out of 24 as compared to vitiligo patients (P < 0.001). CONCLUSION: There is significant negative correlation between HLA-G expression and vitiligo. In our mind, upregulation of HLA-G expression in lesional skin could be local (superficial expression) or systemic (soluble HLA-G isoforms) compensation to restore normal pigmentation in lesions. Medknow Publications 2010 /pmc/articles/PMC2856368/ /pubmed/20418972 http://dx.doi.org/10.4103/0019-5154.60346 Text en © Indian Journal of Dermatology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Research
Jalel, Akrem
Ridha, Aouadi
Laurent, Duboisier
Philippe, Moureaux
Hamdaoui, M H
IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS
title IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS
title_full IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS
title_fullStr IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS
title_full_unstemmed IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS
title_short IMPACT OF HLA-G IN THE OUTCOME OF VITILIGO IN TUNISIAN PATIENTS
title_sort impact of hla-g in the outcome of vitiligo in tunisian patients
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856368/
https://www.ncbi.nlm.nih.gov/pubmed/20418972
http://dx.doi.org/10.4103/0019-5154.60346
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