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CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION
BACKGROUND: Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is a polygenic disease and is associated with autoimmunity with an unknown etiology. AIMS: One of the candidate genes wh...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856369/ https://www.ncbi.nlm.nih.gov/pubmed/20418973 http://dx.doi.org/10.4103/0019-5154.60347 |
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author | Deeba, Farha Syed, Rabbani Quareen, Jariya Waheed, MA Jamil, Kaiser Rao, Hanmanth |
author_facet | Deeba, Farha Syed, Rabbani Quareen, Jariya Waheed, MA Jamil, Kaiser Rao, Hanmanth |
author_sort | Deeba, Farha |
collection | PubMed |
description | BACKGROUND: Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is a polygenic disease and is associated with autoimmunity with an unknown etiology. AIMS: One of the candidate genes which has a strong association with several autoimmune diseases is CTLA-4 gene located in chromosome 2q33 region. We investigated the possible association between CTLA-4 gene polymorphism in exon 1 (A49G) and vitiligo in patients from South India and compared the distribution of this polymorphism to matched control groups. PATIENTS AND METHODS: The polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 175 patients and 180 normal, age/ethnicity matched individuals. Consistency of genotype frequencies with the Hardy-Weinberg equilibrium was tested using a χ(2) test. RESULTS: There was no significant difference between the genotype (P = 0.93) and allele (P = 0.615) frequencies of CTLA-4 A49G polymorphism in patients and normal healthy individuals. However there was significant association of the CTLA-4 genotype (P = 0.02) and allelic frequency (P = 0.008) between the segmental and non-segmental sub groups within vitiligo. CONCLUSION: Our results indicate that there is no association between CTLA-4 A49G gene polymorphism and vitiligo in southern Indian population. |
format | Text |
id | pubmed-2856369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28563692010-04-25 CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION Deeba, Farha Syed, Rabbani Quareen, Jariya Waheed, MA Jamil, Kaiser Rao, Hanmanth Indian J Dermatol Basic Research BACKGROUND: Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is a polygenic disease and is associated with autoimmunity with an unknown etiology. AIMS: One of the candidate genes which has a strong association with several autoimmune diseases is CTLA-4 gene located in chromosome 2q33 region. We investigated the possible association between CTLA-4 gene polymorphism in exon 1 (A49G) and vitiligo in patients from South India and compared the distribution of this polymorphism to matched control groups. PATIENTS AND METHODS: The polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 175 patients and 180 normal, age/ethnicity matched individuals. Consistency of genotype frequencies with the Hardy-Weinberg equilibrium was tested using a χ(2) test. RESULTS: There was no significant difference between the genotype (P = 0.93) and allele (P = 0.615) frequencies of CTLA-4 A49G polymorphism in patients and normal healthy individuals. However there was significant association of the CTLA-4 genotype (P = 0.02) and allelic frequency (P = 0.008) between the segmental and non-segmental sub groups within vitiligo. CONCLUSION: Our results indicate that there is no association between CTLA-4 A49G gene polymorphism and vitiligo in southern Indian population. Medknow Publications 2010 /pmc/articles/PMC2856369/ /pubmed/20418973 http://dx.doi.org/10.4103/0019-5154.60347 Text en © Indian Journal of Dermatology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Deeba, Farha Syed, Rabbani Quareen, Jariya Waheed, MA Jamil, Kaiser Rao, Hanmanth CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION |
title | CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION |
title_full | CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION |
title_fullStr | CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION |
title_full_unstemmed | CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION |
title_short | CTLA-4 A49G GENE POLYMORPHISM IS NOT ASSOCIATED WITH VITILIGO IN SOUTH INDIAN POPULATION |
title_sort | ctla-4 a49g gene polymorphism is not associated with vitiligo in south indian population |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856369/ https://www.ncbi.nlm.nih.gov/pubmed/20418973 http://dx.doi.org/10.4103/0019-5154.60347 |
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