Selective Estrogen Receptor Down-Regulator and Selective Estrogen Receptor Modulators Differentially Regulate Lactotroph Proliferation

BACKGROUND: We recently reported that estrogen receptor α (ERα), even in absence of estrogen (E2), plays a critical role in lactotroph homeostasis. The anti-estrogen ICI 182780 (ICI), but not tamoxifen or raloxifene, rapidly promoted the degradation of ERα, and inhibited cell proliferation. However,...

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Detalles Bibliográficos
Autores principales: Kansra, Sanjay, Chen, Shenglin, Bangaru, Madhavi Latha Yadav, Sneade, Leighton, Dunckley, Joseph A., Ben-Jonathan, Nira
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856675/
https://www.ncbi.nlm.nih.gov/pubmed/20419096
http://dx.doi.org/10.1371/journal.pone.0010060

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