Cyclin B–Cdk1 activates its own pump to get into the nucleus

The transition to mitosis requires extensive nuclear and cytoplasmic rearrangements that must be spatially and temporally coordinated. In this issue, Gavet and Pines (2010a. J. Cell Biol. doi:10.1083/jcb.200909144) report on a simple yet elegant mechanism as to how this is achieved. By monitoring th...

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Detalles Bibliográficos
Autor principal: Lindqvist, Arne
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856906/
https://www.ncbi.nlm.nih.gov/pubmed/20404105
http://dx.doi.org/10.1083/jcb.201003032
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author Lindqvist, Arne
author_facet Lindqvist, Arne
author_sort Lindqvist, Arne
collection PubMed
description The transition to mitosis requires extensive nuclear and cytoplasmic rearrangements that must be spatially and temporally coordinated. In this issue, Gavet and Pines (2010a. J. Cell Biol. doi:10.1083/jcb.200909144) report on a simple yet elegant mechanism as to how this is achieved. By monitoring the activity of cyclin B–Cdk1 in real time, the authors show that concomitant with its activation in the cytoplasm, the kinase complex is rapidly imported into the nucleus by modifying the activity of the nucleocytoplasmic transport machinery. Thus, cyclin B–Cdk1 activates its own pump to get into the nucleus.
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spelling pubmed-28569062010-10-19 Cyclin B–Cdk1 activates its own pump to get into the nucleus Lindqvist, Arne J Cell Biol Reviews The transition to mitosis requires extensive nuclear and cytoplasmic rearrangements that must be spatially and temporally coordinated. In this issue, Gavet and Pines (2010a. J. Cell Biol. doi:10.1083/jcb.200909144) report on a simple yet elegant mechanism as to how this is achieved. By monitoring the activity of cyclin B–Cdk1 in real time, the authors show that concomitant with its activation in the cytoplasm, the kinase complex is rapidly imported into the nucleus by modifying the activity of the nucleocytoplasmic transport machinery. Thus, cyclin B–Cdk1 activates its own pump to get into the nucleus. The Rockefeller University Press 2010-04-19 /pmc/articles/PMC2856906/ /pubmed/20404105 http://dx.doi.org/10.1083/jcb.201003032 Text en © 2010 Lindqvist This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Lindqvist, Arne
Cyclin B–Cdk1 activates its own pump to get into the nucleus
title Cyclin B–Cdk1 activates its own pump to get into the nucleus
title_full Cyclin B–Cdk1 activates its own pump to get into the nucleus
title_fullStr Cyclin B–Cdk1 activates its own pump to get into the nucleus
title_full_unstemmed Cyclin B–Cdk1 activates its own pump to get into the nucleus
title_short Cyclin B–Cdk1 activates its own pump to get into the nucleus
title_sort cyclin b–cdk1 activates its own pump to get into the nucleus
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856906/
https://www.ncbi.nlm.nih.gov/pubmed/20404105
http://dx.doi.org/10.1083/jcb.201003032
work_keys_str_mv AT lindqvistarne cyclinbcdk1activatesitsownpumptogetintothenucleus

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