Cargando…

Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2

The reversible association and dissociation of a metabolic multi-enzyme complex participating in de novo purine biosynthesis, the purinosome, was demonstrated in live cells to respond to the levels of purine nucleotides in the culture media. We also took advantage of in vitro proteomic scale studies...

Descripción completa

Detalles Bibliográficos
Autores principales:	An, Songon, Kyoung, Minjoung, Allen, Jasmina J., Shokat, Kevan M., Benkovic, Stephen J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856985/ https://www.ncbi.nlm.nih.gov/pubmed/20157113 http://dx.doi.org/10.1074/jbc.M110.101139

Ejemplares similares

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis
por: Verrier, Florence, et al.
Publicado: (2011)

Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF–ERK1/2 signaling pathways
por: Jeon, Miji, et al.
Publicado: (2022)

Size-Specific Modulation of a Multienzyme Glucosome Assembly during the Cell Cycle
por: Jeon, Miji, et al.
Publicado: (2023)

Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90
por: Pedley, Anthony M., et al.
Publicado: (2022)

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
por: Burger, Karen L., et al.
Publicado: (2023)

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors
por: Lazarus, Michael B., et al.
Publicado: (2014)

A Mathematical Model for Enzyme Clustering in Glucose Metabolism
por: Jeon, Miji, et al.
Publicado: (2018)

In Vivo Conditions to Identify Prkci Phosphorylation Targets Using the Analog-Sensitive Kinase Method in Zebrafish
por: Cibrián Uhalte, Elena, et al.
Publicado: (2012)

Kinetic data for modeling the dynamics of the enzymes involved in animal fatty acid synthesis
por: Foko Kuate, Chilperic Armel, et al.
Publicado: (2023)

Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a
por: Kakiya, Naomasa, et al.
Publicado: (2012)

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
por: Larochelle, Stéphane, et al.
Publicado: (2012)

The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes, and Focal Creatine Deposits
por: Bürklen, Tanja S., et al.
Publicado: (2006)

Chemical Genetic Analysis of Protein Kinase Cascades
por: Alaimo, Peter J., et al.
Publicado: (2002)

High-throughput screening identifies cell cycle-associated signaling cascades that regulate a multienzyme glucosome assembly in human cells
por: Schmitt, Danielle L., et al.
Publicado: (2023)

Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer
por: Guerra, Barbara, et al.
Publicado: (2020)

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders
por: Baier, Andrea, et al.
Publicado: (2022)

Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model
por: Amrutkar, Manoj, et al.
Publicado: (2015)

Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
por: Jurczak, Michael J., et al.
Publicado: (2012)

Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex
por: Tabata, Mitsuhisa, et al.
Publicado: (2014)

Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2
por: Spinello, Zaira, et al.
Publicado: (2021)

An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes
por: Custodio, Joseph M., et al.
Publicado: (2020)

Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress
por: Kolwicz, Stephen C., et al.
Publicado: (2015)

Hypothalamic Protein Kinase C Regulates Glucose Production
por: Ross, Rachel, et al.
Publicado: (2008)

The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole
por: Elmore, Zachary C., et al.
Publicado: (2018)

Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation
por: Graciotti, Michele, et al.
Publicado: (2014)

The Multiple Personalities of the Regulatory Subunit of Protein Kinase CK2: CK2 Dependent and CK2 Independent Roles Reveal a Secret Identity for CK2β
por: Bibby, Ashley C., et al.
Publicado: (2005)

Protein Kinase CK2 in Cancer Energetics
por: Silva-Pavez, Eduardo, et al.
Publicado: (2020)

Severity of Diabetes Governs Vascular Lipoprotein Lipase by Affecting Enzyme Dimerization and Disassembly
por: Wang, Ying, et al.
Publicado: (2011)

A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5
por: Tudhope, Susan J., et al.
Publicado: (2012)

Effects of supplemental zinc source and level on antioxidant ability and fat metabolism-related enzymes of broilers
por: Liu, Z. H., et al.
Publicado: (2015)

Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding
por: Li, Ai-Jun, et al.
Publicado: (2011)

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
por: Yang, Clair S., et al.
Publicado: (2010)

Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver
por: Winnick, Jason J., et al.
Publicado: (2011)

Plasma Levels of Fetuin-A and Hepatic Enzymes and Risk of Type 2 Diabetes in Women in the U.S.
por: Sun, Qi, et al.
Publicado: (2013)

Sex-dependent dynamics of metabolism in primary mouse hepatocytes
por: Hochmuth, Luise, et al.
Publicado: (2021)

Pyruvate Dehydrogenase Kinase 4: Regulation by Thiazolidinediones and Implication in Glyceroneogenesis in Adipose Tissue
por: Cadoudal, Thomas, et al.
Publicado: (2008)

Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance
por: Williams, Ashley S., et al.
Publicado: (2017)

Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin Secretion, and Glucagon Concentration in Healthy Men and Women
por: Bonnet, Fabrice, et al.
Publicado: (2011)

Metabolism-Independent Sugar Sensing in Central Orexin Neurons
por: González, J. Antonio, et al.
Publicado: (2008)

Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development
por: Bandyopadhyay, Mohna, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_36pqhagrk6l8q4sko11i3a9a33