Cargando…

Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates

γ-Secretase is a ubiquitous, multiprotein enzyme composed of presenilin, nicastrin, Aph-1, and Pen-2. It mediates the intramembrane proteolysis of many type 1 proteins, plays an essential role in numerous signaling pathways, and helps drive the pathogenesis of Alzheimer disease by excising the hydro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Allen C., Guo, Lucie Y., Ostaszewski, Beth L., Selkoe, Dennis J., LaVoie, Matthew J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857016/ https://www.ncbi.nlm.nih.gov/pubmed/20145246 http://dx.doi.org/10.1074/jbc.M109.088815

Ejemplares similares

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space
por: Perez-Gonzalez, Rocio, et al.
Publicado: (2012)

Specific Mutations in Aph1 Cause γ-Secretase Activation
por: Watanabe, Hikari, et al.
Publicado: (2022)

Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation
por: Ding, Yun, et al.
Publicado: (2012)

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
por: Hemming, Matthew L, et al.
Publicado: (2008)

Proinflammatory cytokines induce accumulation of glypican-1-derived heparan sulfate and the C-terminal fragment of β-cleaved APP in autophagosomes of dividing neuronal cells
por: Cheng, Fang, et al.
Publicado: (2020)

γ-Aminobutyric Acid Type A (GABA(A)) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains
por: Brown, Laura E., et al.
Publicado: (2016)

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
por: Liu, Lei, et al.
Publicado: (2019)

Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals
por: Marland, Jamie Roslin Keynes, et al.
Publicado: (2016)

Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators
por: Dohrke, Jan-Niklas, et al.
Publicado: (2020)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates
por: Bhat, Shreyas, et al.
Publicado: (2017)

Dopamine Transporter Phosphorylation Site Threonine 53 Regulates Substrate Reuptake and Amphetamine-stimulated Efflux
por: Foster, James D., et al.
Publicado: (2012)

A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABA(A)), Receptor Subunit Binding Selectivity in Synaptosomes
por: Woll, Kellie A., et al.
Publicado: (2016)

Different cofactor activities in γ-secretase assembly: evidence for a nicastrin–Aph-1 subcomplex
por: Hu, Yue, et al.
Publicado: (2003)

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses
por: Ninkina, Natalia, et al.
Publicado: (2012)

The Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) C Terminus Plays a Key Role in Protein Stability, but Its Farnesylation Is Not Required for Membrane Association in Primary Neurons
por: Bishop, Paul, et al.
Publicado: (2014)

Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABA(B) Receptors to Lysosomal Degradation
por: Zemoura, Khaled, et al.
Publicado: (2016)

Pituitary Adenylate Cyclase-activating Polypeptide (PACAP)/PAC(1)HOP1 Receptor Activation Coordinates Multiple Neurotrophic Signaling Pathways: Akt ACTIVATION THROUGH PHOSPHATIDYLINOSITOL 3-KINASE γ AND VESICLE ENDOCYTOSIS FOR NEURONAL SURVIVAL
por: May, Victor, et al.
Publicado: (2010)

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling
por: Fazzari, Pietro, et al.
Publicado: (2014)

α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species
por: Morgan, Sophie A., et al.
Publicado: (2020)

A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria
por: Scott, Helen L., et al.
Publicado: (2020)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
por: Hemming, Matthew L., et al.
Publicado: (2009)

Rer1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway
por: Spasic, Dragana, et al.
Publicado: (2007)

Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
por: Barão, Soraia, et al.
Publicado: (2015)

Spatial facilitation by a high-performance dragonfly target-detecting neuron
por: Nordström, Karin, et al.
Publicado: (2011)

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses
por: Verpelli, Chiara, et al.
Publicado: (2011)

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation
por: Zucchelli, Silvia, et al.
Publicado: (2011)

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors
por: Jiang, Peng, et al.
Publicado: (2010)

The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines
por: Sucic, Sonja, et al.
Publicado: (2010)

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo
por: Lou, Haiyan, et al.
Publicado: (2010)

The Longin SNARE VAMP7/TI-VAMP Adopts a Closed Conformation
por: Vivona, Sandro, et al.
Publicado: (2010)

High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex
por: Boucard, Antony A., et al.
Publicado: (2012)

20-Hydroxyeicosatetraenoic Acid (20-HETE) Is a Novel Activator of Transient Receptor Potential Vanilloid 1 (TRPV1) Channel
por: Wen, Hairuo, et al.
Publicado: (2012)

Allele-specific Differences in Activity of a Novel Cannabinoid Receptor 1 (CNR1) Gene Intronic Enhancer in Hypothalamus, Dorsal Root Ganglia, and Hippocampus
por: Nicoll, Gemma, et al.
Publicado: (2012)

Krüppel-like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells
por: Seo, Seungmae, et al.
Publicado: (2012)

Vertebrate ancient opsin photopigment spectra and the avian photoperiodic response
por: Davies, Wayne I. L., et al.
Publicado: (2012)

Extrasynaptic N-Methyl-d-aspartate (NMDA) Receptor Stimulation Induces Cytoplasmic Translocation of the CDKL5 Kinase and Its Proteasomal Degradation
por: Rusconi, Laura, et al.
Publicado: (2011)

Alternative Splicing Modulates Inactivation of Type 1 Voltage-gated Sodium Channels by Toggling an Amino Acid in the First S3-S4 Linker
por: Fletcher, Emily V., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_1drmrlli0go4sd5r5hd3seqls8