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MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ

MutSβ (MSH2-MSH3) mediates repair of insertion-deletion heterologies but also triggers triplet repeat expansions that cause neurological diseases. Like other DNA metabolic activities, MutSβ interacts with proliferating cell nuclear antigen (PCNA) via a conserved motif (QXX(L/I)XXFF). We demonstrate...

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Detalles Bibliográficos
Autores principales:	Iyer, Ravi R., Pluciennik, Anna, Genschel, Jochen, Tsai, Miaw-Sheue, Beese, Lorena S., Modrich, Paul
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857047/ https://www.ncbi.nlm.nih.gov/pubmed/20154325 http://dx.doi.org/10.1074/jbc.M110.104125

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