Reduced Sensitivity of Influenza A (H5N1) to Oseltamivir

We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A virus (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared to the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fo...

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Detalles Bibliográficos
Autores principales: McKimm-Breschkin, Jennifer L., Selleck, Paul W., Usman, Tri Bhakti, Johnson, Michael A.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2007
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857286/
https://www.ncbi.nlm.nih.gov/pubmed/18252107
http://dx.doi.org/10.3201/eid1309.07-0164
Descripción
Sumario:We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A virus (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared to the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.

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