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Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa

3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C–F, viscosamine, viscosaline and a cyclic monomer. All of them we...

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Detalles Bibliográficos
Autores principales: Timm, Christoph, Mordhorst, Thorsten, Köck, Matthias
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857371/
https://www.ncbi.nlm.nih.gov/pubmed/20411111
http://dx.doi.org/10.3390/md8030483
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author Timm, Christoph
Mordhorst, Thorsten
Köck, Matthias
author_facet Timm, Christoph
Mordhorst, Thorsten
Köck, Matthias
author_sort Timm, Christoph
collection PubMed
description 3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C–F, viscosamine, viscosaline and a cyclic monomer. All of them were isolated from the Arctic sponge Haliclona viscosa collected in Spitsbergen, Norway. In this article we report the syntheses of these secondary metabolites from Haliclona viscosa and related compounds and give a short overview of the bioactivity.
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spelling pubmed-28573712010-04-21 Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa Timm, Christoph Mordhorst, Thorsten Köck, Matthias Mar Drugs Review 3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C–F, viscosamine, viscosaline and a cyclic monomer. All of them were isolated from the Arctic sponge Haliclona viscosa collected in Spitsbergen, Norway. In this article we report the syntheses of these secondary metabolites from Haliclona viscosa and related compounds and give a short overview of the bioactivity. Molecular Diversity Preservation International 2010-03-05 /pmc/articles/PMC2857371/ /pubmed/20411111 http://dx.doi.org/10.3390/md8030483 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Timm, Christoph
Mordhorst, Thorsten
Köck, Matthias
Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
title Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
title_full Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
title_fullStr Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
title_full_unstemmed Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
title_short Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa
title_sort synthesis of 3-alkyl pyridinium alkaloids from the arctic sponge haliclona viscosa
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857371/
https://www.ncbi.nlm.nih.gov/pubmed/20411111
http://dx.doi.org/10.3390/md8030483
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