c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage

Type I invariant NKT cells (iNKT) are a subset of αβ T cells characterized by the expression of an invariant Vα14-Jα18 TCRα chain. iNKT cells derive from CD4(+)CD8(+) double positive thymocytes (DP), and their generation requires a long DP thymocyte half-life, to allow for Vα14-Jα18 rearrangements,...

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Detalles Bibliográficos
Autores principales: Hu, Taishan, Simmons, Amie, Yuan, Joan, Bender, Timothy P., Alberola-Ila, Jose
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857587/
https://www.ncbi.nlm.nih.gov/pubmed/20383148
http://dx.doi.org/10.1038/ni.1865
Descripción
Sumario:Type I invariant NKT cells (iNKT) are a subset of αβ T cells characterized by the expression of an invariant Vα14-Jα18 TCRα chain. iNKT cells derive from CD4(+)CD8(+) double positive thymocytes (DP), and their generation requires a long DP thymocyte half-life, to allow for Vα14-Jα18 rearrangements, expression of glycolipid-loaded CD1d on DP thymocytes, and signaling through the SLAM/SAP pathway. Here we show that c-Myb plays a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, DP half-life, and expression of SLAMF1, SLAMF6 and SAP.

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