c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage

Type I invariant NKT cells (iNKT) are a subset of αβ T cells characterized by the expression of an invariant Vα14-Jα18 TCRα chain. iNKT cells derive from CD4(+)CD8(+) double positive thymocytes (DP), and their generation requires a long DP thymocyte half-life, to allow for Vα14-Jα18 rearrangements,...

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Detalles Bibliográficos
Autores principales: Hu, Taishan, Simmons, Amie, Yuan, Joan, Bender, Timothy P., Alberola-Ila, Jose
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857587/
https://www.ncbi.nlm.nih.gov/pubmed/20383148
http://dx.doi.org/10.1038/ni.1865
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author Hu, Taishan
Simmons, Amie
Yuan, Joan
Bender, Timothy P.
Alberola-Ila, Jose
author_facet Hu, Taishan
Simmons, Amie
Yuan, Joan
Bender, Timothy P.
Alberola-Ila, Jose
author_sort Hu, Taishan
collection PubMed
description Type I invariant NKT cells (iNKT) are a subset of αβ T cells characterized by the expression of an invariant Vα14-Jα18 TCRα chain. iNKT cells derive from CD4(+)CD8(+) double positive thymocytes (DP), and their generation requires a long DP thymocyte half-life, to allow for Vα14-Jα18 rearrangements, expression of glycolipid-loaded CD1d on DP thymocytes, and signaling through the SLAM/SAP pathway. Here we show that c-Myb plays a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, DP half-life, and expression of SLAMF1, SLAMF6 and SAP.
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spelling pubmed-28575872010-11-01 c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage Hu, Taishan Simmons, Amie Yuan, Joan Bender, Timothy P. Alberola-Ila, Jose Nat Immunol Article Type I invariant NKT cells (iNKT) are a subset of αβ T cells characterized by the expression of an invariant Vα14-Jα18 TCRα chain. iNKT cells derive from CD4(+)CD8(+) double positive thymocytes (DP), and their generation requires a long DP thymocyte half-life, to allow for Vα14-Jα18 rearrangements, expression of glycolipid-loaded CD1d on DP thymocytes, and signaling through the SLAM/SAP pathway. Here we show that c-Myb plays a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, DP half-life, and expression of SLAMF1, SLAMF6 and SAP. 2010-04-11 2010-05 /pmc/articles/PMC2857587/ /pubmed/20383148 http://dx.doi.org/10.1038/ni.1865 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hu, Taishan
Simmons, Amie
Yuan, Joan
Bender, Timothy P.
Alberola-Ila, Jose
c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
title c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
title_full c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
title_fullStr c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
title_full_unstemmed c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
title_short c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
title_sort c-myb primes cd4(+)cd8(+) immature thymocytes for selection into the inkt lineage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857587/
https://www.ncbi.nlm.nih.gov/pubmed/20383148
http://dx.doi.org/10.1038/ni.1865
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