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Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans
The renin angiotensin system (RAS) has profound effects on atherosclerosis development in animal models, which is partially complimented by evidence in the human disease. Although angiotensin II was considered to be the principal effector of the RAS, a broader array of bioactive angiotensin peptides...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Current Science Inc.
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857789/ https://www.ncbi.nlm.nih.gov/pubmed/20425255 http://dx.doi.org/10.1007/s11883-010-0109-4 |
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author | Daugherty, Alan Poduri, Aruna Chen, Xiaofeng Lu, Hong Cassis, Lisa A. |
author_facet | Daugherty, Alan Poduri, Aruna Chen, Xiaofeng Lu, Hong Cassis, Lisa A. |
author_sort | Daugherty, Alan |
collection | PubMed |
description | The renin angiotensin system (RAS) has profound effects on atherosclerosis development in animal models, which is partially complimented by evidence in the human disease. Although angiotensin II was considered to be the principal effector of the RAS, a broader array of bioactive angiotensin peptides have been identified that have increased the scope of enzymes and receptors in the RAS. Genetic interruption of the synthesis of these peptides has not been extensively performed in experimental or human studies. A few studies demonstrate that interruption of a component of the angiotensin peptide synthesis pathway reduces experimental lesion formation. The evidence in human studies has not been consistent. Conversely, genetic manipulation of the RAS receptors has demonstrated that AT1a receptors are profoundly involved in experimental atherosclerosis. Few studies have reported links of genetic variants of angiotensin II receptors to human atherosclerotic diseases. Further genetic studies are needed to define the role of RAS in atherosclerosis. |
format | Text |
id | pubmed-2857789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Current Science Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-28577892010-04-27 Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans Daugherty, Alan Poduri, Aruna Chen, Xiaofeng Lu, Hong Cassis, Lisa A. Curr Atheroscler Rep Article The renin angiotensin system (RAS) has profound effects on atherosclerosis development in animal models, which is partially complimented by evidence in the human disease. Although angiotensin II was considered to be the principal effector of the RAS, a broader array of bioactive angiotensin peptides have been identified that have increased the scope of enzymes and receptors in the RAS. Genetic interruption of the synthesis of these peptides has not been extensively performed in experimental or human studies. A few studies demonstrate that interruption of a component of the angiotensin peptide synthesis pathway reduces experimental lesion formation. The evidence in human studies has not been consistent. Conversely, genetic manipulation of the RAS receptors has demonstrated that AT1a receptors are profoundly involved in experimental atherosclerosis. Few studies have reported links of genetic variants of angiotensin II receptors to human atherosclerotic diseases. Further genetic studies are needed to define the role of RAS in atherosclerosis. Current Science Inc. 2010-03-31 2010 /pmc/articles/PMC2857789/ /pubmed/20425255 http://dx.doi.org/10.1007/s11883-010-0109-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Daugherty, Alan Poduri, Aruna Chen, Xiaofeng Lu, Hong Cassis, Lisa A. Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans |
title | Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans |
title_full | Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans |
title_fullStr | Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans |
title_full_unstemmed | Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans |
title_short | Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans |
title_sort | genetic variants of the renin angiotensin system: effects on atherosclerosis in experimental models and humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857789/ https://www.ncbi.nlm.nih.gov/pubmed/20425255 http://dx.doi.org/10.1007/s11883-010-0109-4 |
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