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Sensitivity of genomic selection to using different prior distributions

Genomic selection describes a selection strategy based on genomic estimated breeding values (GEBV) predicted from dense genetic markers such as single nucleotide polymorphism (SNP) data. Different Bayesian models have been suggested to derive the prediction equation, with the main difference centred...

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Detalles Bibliográficos
Autores principales: Verbyla, Klara L, Bowman, Philip J, Hayes, Ben J, Goddard, Michael E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857847/
https://www.ncbi.nlm.nih.gov/pubmed/20380759
http://dx.doi.org/10.1186/1753-6561-4-S1-S5
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author Verbyla, Klara L
Bowman, Philip J
Hayes, Ben J
Goddard, Michael E
author_facet Verbyla, Klara L
Bowman, Philip J
Hayes, Ben J
Goddard, Michael E
author_sort Verbyla, Klara L
collection PubMed
description Genomic selection describes a selection strategy based on genomic estimated breeding values (GEBV) predicted from dense genetic markers such as single nucleotide polymorphism (SNP) data. Different Bayesian models have been suggested to derive the prediction equation, with the main difference centred around the specification of the prior distributions. METHODS: The simulated dataset of the 13(th) QTL-MAS workshop was analysed using four Bayesian approaches to predict GEBV for animals without phenotypic information. Different prior distributions were assumed to assess their affect on the accuracy of the predicted GEBV. CONCLUSION: All methods produced GEBV that were highly correlated with the true breeding values. The models appear relatively insensitive to the choice of prior distributions for QTL-MAS data set and this is consistent with uniformity of performance of different methods found in real data.
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spelling pubmed-28578472010-04-22 Sensitivity of genomic selection to using different prior distributions Verbyla, Klara L Bowman, Philip J Hayes, Ben J Goddard, Michael E BMC Proc Proceedings Genomic selection describes a selection strategy based on genomic estimated breeding values (GEBV) predicted from dense genetic markers such as single nucleotide polymorphism (SNP) data. Different Bayesian models have been suggested to derive the prediction equation, with the main difference centred around the specification of the prior distributions. METHODS: The simulated dataset of the 13(th) QTL-MAS workshop was analysed using four Bayesian approaches to predict GEBV for animals without phenotypic information. Different prior distributions were assumed to assess their affect on the accuracy of the predicted GEBV. CONCLUSION: All methods produced GEBV that were highly correlated with the true breeding values. The models appear relatively insensitive to the choice of prior distributions for QTL-MAS data set and this is consistent with uniformity of performance of different methods found in real data. BioMed Central 2010-03-31 /pmc/articles/PMC2857847/ /pubmed/20380759 http://dx.doi.org/10.1186/1753-6561-4-S1-S5 Text en Copyright ©2010 Verbyla et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Verbyla, Klara L
Bowman, Philip J
Hayes, Ben J
Goddard, Michael E
Sensitivity of genomic selection to using different prior distributions
title Sensitivity of genomic selection to using different prior distributions
title_full Sensitivity of genomic selection to using different prior distributions
title_fullStr Sensitivity of genomic selection to using different prior distributions
title_full_unstemmed Sensitivity of genomic selection to using different prior distributions
title_short Sensitivity of genomic selection to using different prior distributions
title_sort sensitivity of genomic selection to using different prior distributions
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857847/
https://www.ncbi.nlm.nih.gov/pubmed/20380759
http://dx.doi.org/10.1186/1753-6561-4-S1-S5
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