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Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes

OBJECTIVE: Mean blood glucose (MBG) and MBG-independent factors both influence A1C levels. Race was related to A1C independent of MBG in adults. The goal of this study was to determine if racial disparity exists in A1C independent of MBG in children with diabetes. RESEARCH DESIGN AND METHODS: Partic...

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Detalles Bibliográficos
Autores principales: Kamps, Jodi L., Hempe, James M., Chalew, Stuart A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858167/
https://www.ncbi.nlm.nih.gov/pubmed/20185743
http://dx.doi.org/10.2337/dc09-1440
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author Kamps, Jodi L.
Hempe, James M.
Chalew, Stuart A.
author_facet Kamps, Jodi L.
Hempe, James M.
Chalew, Stuart A.
author_sort Kamps, Jodi L.
collection PubMed
description OBJECTIVE: Mean blood glucose (MBG) and MBG-independent factors both influence A1C levels. Race was related to A1C independent of MBG in adults. The goal of this study was to determine if racial disparity exists in A1C independent of MBG in children with diabetes. RESEARCH DESIGN AND METHODS: Participants included 276 children with type 1 diabetes. A1C and MBG were obtained from multiple clinic visits, and a hemoglobin glycation index (HGI) (an assessment of A1C levels independent of MBG) was calculated. A1C and HGI were analyzed controlling for age, diabetes duration, and MBG. RESULTS: African Americans had statistically significantly higher A1C (9.1 ± 0.1) and HGI (0.64 ± 0.11) than Caucasians (A1C 8.3 ± 0.1, HGI −0.15 ± 0.07) independent of covariates. CONCLUSIONS: Because of racial disparity in A1C, which is independent of MBG, we recommend that A1C and MBG be used together to make therapeutic decisions for children with diabetes.
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spelling pubmed-28581672011-05-01 Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes Kamps, Jodi L. Hempe, James M. Chalew, Stuart A. Diabetes Care Original Research OBJECTIVE: Mean blood glucose (MBG) and MBG-independent factors both influence A1C levels. Race was related to A1C independent of MBG in adults. The goal of this study was to determine if racial disparity exists in A1C independent of MBG in children with diabetes. RESEARCH DESIGN AND METHODS: Participants included 276 children with type 1 diabetes. A1C and MBG were obtained from multiple clinic visits, and a hemoglobin glycation index (HGI) (an assessment of A1C levels independent of MBG) was calculated. A1C and HGI were analyzed controlling for age, diabetes duration, and MBG. RESULTS: African Americans had statistically significantly higher A1C (9.1 ± 0.1) and HGI (0.64 ± 0.11) than Caucasians (A1C 8.3 ± 0.1, HGI −0.15 ± 0.07) independent of covariates. CONCLUSIONS: Because of racial disparity in A1C, which is independent of MBG, we recommend that A1C and MBG be used together to make therapeutic decisions for children with diabetes. American Diabetes Association 2010-05 2010-02-25 /pmc/articles/PMC2858167/ /pubmed/20185743 http://dx.doi.org/10.2337/dc09-1440 Text en © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Kamps, Jodi L.
Hempe, James M.
Chalew, Stuart A.
Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes
title Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes
title_full Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes
title_fullStr Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes
title_full_unstemmed Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes
title_short Racial Disparity in A1C Independent of Mean Blood Glucose in Children With Type 1 Diabetes
title_sort racial disparity in a1c independent of mean blood glucose in children with type 1 diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858167/
https://www.ncbi.nlm.nih.gov/pubmed/20185743
http://dx.doi.org/10.2337/dc09-1440
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