No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study

OBJECTIVE: Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes. RESEARCH DESIGN AND METHODS: A nested case-control design was used to test for any association between the development...

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Detalles Bibliográficos
Autores principales: Tapia, German, Cinek, Ondrej, Rasmussen, Trond, Grinde, Bjørn, Rønningen, Kjersti S.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858177/
https://www.ncbi.nlm.nih.gov/pubmed/20185738
http://dx.doi.org/10.2337/dc09-1951
Descripción
Sumario:OBJECTIVE: Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes. RESEARCH DESIGN AND METHODS: A nested case-control design was used to test for any association between the development of pre-diabetic autoimmunity and presence of LjV in stool samples (n = 3,803) in the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) study. The children followed were 27 infants who developed pre-diabetic autoimmunity during or shortly after the sampling period, 54 matched control subjects, and 94 other children. RESULTS: No LjV RNA was detected. CONCLUSIONS: The results indicate that LjV is rare in young children. LjV does not seem to be involved in the development of human type 1 diabetes.

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