No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study

OBJECTIVE: Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes. RESEARCH DESIGN AND METHODS: A nested case-control design was used to test for any association between the development...

Descripción completa

Detalles Bibliográficos
Autores principales: Tapia, German, Cinek, Ondrej, Rasmussen, Trond, Grinde, Bjørn, Rønningen, Kjersti S.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858177/
https://www.ncbi.nlm.nih.gov/pubmed/20185738
http://dx.doi.org/10.2337/dc09-1951
_version_ 1782180400769007616
author Tapia, German
Cinek, Ondrej
Rasmussen, Trond
Grinde, Bjørn
Rønningen, Kjersti S.
author_facet Tapia, German
Cinek, Ondrej
Rasmussen, Trond
Grinde, Bjørn
Rønningen, Kjersti S.
author_sort Tapia, German
collection PubMed
description OBJECTIVE: Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes. RESEARCH DESIGN AND METHODS: A nested case-control design was used to test for any association between the development of pre-diabetic autoimmunity and presence of LjV in stool samples (n = 3,803) in the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) study. The children followed were 27 infants who developed pre-diabetic autoimmunity during or shortly after the sampling period, 54 matched control subjects, and 94 other children. RESULTS: No LjV RNA was detected. CONCLUSIONS: The results indicate that LjV is rare in young children. LjV does not seem to be involved in the development of human type 1 diabetes.
format Text
id pubmed-2858177
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-28581772011-05-01 No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study Tapia, German Cinek, Ondrej Rasmussen, Trond Grinde, Bjørn Rønningen, Kjersti S. Diabetes Care Original Research OBJECTIVE: Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes. RESEARCH DESIGN AND METHODS: A nested case-control design was used to test for any association between the development of pre-diabetic autoimmunity and presence of LjV in stool samples (n = 3,803) in the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) study. The children followed were 27 infants who developed pre-diabetic autoimmunity during or shortly after the sampling period, 54 matched control subjects, and 94 other children. RESULTS: No LjV RNA was detected. CONCLUSIONS: The results indicate that LjV is rare in young children. LjV does not seem to be involved in the development of human type 1 diabetes. American Diabetes Association 2010-05 2010-02-25 /pmc/articles/PMC2858177/ /pubmed/20185738 http://dx.doi.org/10.2337/dc09-1951 Text en © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Tapia, German
Cinek, Ondrej
Rasmussen, Trond
Grinde, Bjørn
Rønningen, Kjersti S.
No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study
title No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study
title_full No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study
title_fullStr No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study
title_full_unstemmed No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study
title_short No Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study
title_sort no ljungan virus rna in stool samples from the norwegian environmental triggers of type 1 diabetes (midia) cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858177/
https://www.ncbi.nlm.nih.gov/pubmed/20185738
http://dx.doi.org/10.2337/dc09-1951
work_keys_str_mv AT tapiagerman noljunganvirusrnainstoolsamplesfromthenorwegianenvironmentaltriggersoftype1diabetesmidiacohortstudy
AT cinekondrej noljunganvirusrnainstoolsamplesfromthenorwegianenvironmentaltriggersoftype1diabetesmidiacohortstudy
AT rasmussentrond noljunganvirusrnainstoolsamplesfromthenorwegianenvironmentaltriggersoftype1diabetesmidiacohortstudy
AT grindebjørn noljunganvirusrnainstoolsamplesfromthenorwegianenvironmentaltriggersoftype1diabetesmidiacohortstudy
AT rønningenkjerstis noljunganvirusrnainstoolsamplesfromthenorwegianenvironmentaltriggersoftype1diabetesmidiacohortstudy

Ejemplares similares