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Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation

OBJECTIVE: Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS: Participants were 199 mothers who participated in a randomized controlled trial of...

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Autores principales: Gillman, Matthew W., Oakey, Helena, Baghurst, Peter A., Volkmer, Robert E., Robinson, Jeffrey S., Crowther, Caroline A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858199/
https://www.ncbi.nlm.nih.gov/pubmed/20150300
http://dx.doi.org/10.2337/dc09-1810
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author Gillman, Matthew W.
Oakey, Helena
Baghurst, Peter A.
Volkmer, Robert E.
Robinson, Jeffrey S.
Crowther, Caroline A.
author_facet Gillman, Matthew W.
Oakey, Helena
Baghurst, Peter A.
Volkmer, Robert E.
Robinson, Jeffrey S.
Crowther, Caroline A.
author_sort Gillman, Matthew W.
collection PubMed
description OBJECTIVE: Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS: Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mild GDM during pregnancy and their children. Trained nurses measured the height and weight of the children at preschool visits in a state-wide surveillance program in the state of South Australia. The main outcome measure was age- and sex-specific BMI Z score based on standards of the International Obesity Task Force. RESULTS: At birth, prevalence of macrosomia (birth weight ≥4,000 g) was 5.3% among the 94 children whose mothers were in the intervention group, and 21.9% among the 105 children in the routine care control group. At 4- to 5-years-old, mean (SD) BMI Z score was 0.49 (1.20) in intervention children and 0.41 (1.40) among controls. The difference between treatment groups was 0.08 (95% CI −0.29 to 0.44), an estimate minimally changed by adjustment for maternal race, parity, age, and socio-economic index (0.08 [−0.29 to 0.45]). Evaluating BMI ≥85th percentile rather than continuous BMI Z score gave similarly null results. CONCLUSIONS: Although treatment of GDM substantially reduced macrosomia at birth, it did not result in a change in BMI at age 4- to 5-years-old.
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spelling pubmed-28581992011-05-01 Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation Gillman, Matthew W. Oakey, Helena Baghurst, Peter A. Volkmer, Robert E. Robinson, Jeffrey S. Crowther, Caroline A. Diabetes Care Original Research OBJECTIVE: Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS: Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mild GDM during pregnancy and their children. Trained nurses measured the height and weight of the children at preschool visits in a state-wide surveillance program in the state of South Australia. The main outcome measure was age- and sex-specific BMI Z score based on standards of the International Obesity Task Force. RESULTS: At birth, prevalence of macrosomia (birth weight ≥4,000 g) was 5.3% among the 94 children whose mothers were in the intervention group, and 21.9% among the 105 children in the routine care control group. At 4- to 5-years-old, mean (SD) BMI Z score was 0.49 (1.20) in intervention children and 0.41 (1.40) among controls. The difference between treatment groups was 0.08 (95% CI −0.29 to 0.44), an estimate minimally changed by adjustment for maternal race, parity, age, and socio-economic index (0.08 [−0.29 to 0.45]). Evaluating BMI ≥85th percentile rather than continuous BMI Z score gave similarly null results. CONCLUSIONS: Although treatment of GDM substantially reduced macrosomia at birth, it did not result in a change in BMI at age 4- to 5-years-old. American Diabetes Association 2010-05 2010-02-11 /pmc/articles/PMC2858199/ /pubmed/20150300 http://dx.doi.org/10.2337/dc09-1810 Text en © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Gillman, Matthew W.
Oakey, Helena
Baghurst, Peter A.
Volkmer, Robert E.
Robinson, Jeffrey S.
Crowther, Caroline A.
Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation
title Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation
title_full Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation
title_fullStr Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation
title_full_unstemmed Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation
title_short Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation
title_sort effect of treatment of gestational diabetes mellitus on obesity in the next generation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858199/
https://www.ncbi.nlm.nih.gov/pubmed/20150300
http://dx.doi.org/10.2337/dc09-1810
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