The Impact of Mouse Passaging of Mycobacterium tuberculosis Strains prior to Virulence Testing in the Mouse and Guinea Pig Aerosol Models

BACKGROUND: It has been hypothesized that the virulence of lab-passaged Mycobacterium tuberculosis and recombinant M. tuberculosis mutants might be reduced due to multiple in vitro passages, and that virulence might be augmented by passage of these strains through mice before quantitative virulence...

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Detalles Bibliográficos
Autores principales: Converse, Paul J., Eisenach, Kathleen D., Theus, Sue A., Nuermberger, Eric L., Tyagi, Sandeep, Ly, Lan H., Geiman, Deborah E., Guo, Haidan, Nolan, Scott T., Akar, Nicole C., Klinkenberg, Lee G., Gupta, Radhika, Lun, Shichun, Karakousis, Petros C., Lamichhane, Gyanu, McMurray, David N., Grosset, Jacques H., Bishai, William R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858211/
https://www.ncbi.nlm.nih.gov/pubmed/20422019
http://dx.doi.org/10.1371/journal.pone.0010289

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