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Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex
Although genetics is the most significant known determinant of human intelligence, specific gene contributions remain largely unknown. To accelerate understanding in this area, we have taken a new approach by studying the relationship between quantitative gene expression and intelligence in a cohort...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858212/ https://www.ncbi.nlm.nih.gov/pubmed/20422020 http://dx.doi.org/10.1371/journal.pone.0010292 |
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author | Gao, Michael C. Bellugi, Ursula Dai, Li Mills, Debra L. Sobel, Eric M. Lange, Kenneth Korenberg, Julie R. |
author_facet | Gao, Michael C. Bellugi, Ursula Dai, Li Mills, Debra L. Sobel, Eric M. Lange, Kenneth Korenberg, Julie R. |
author_sort | Gao, Michael C. |
collection | PubMed |
description | Although genetics is the most significant known determinant of human intelligence, specific gene contributions remain largely unknown. To accelerate understanding in this area, we have taken a new approach by studying the relationship between quantitative gene expression and intelligence in a cohort of 65 patients with Williams Syndrome (WS), a neurodevelopmental disorder caused by a 1.5 Mb deletion on chromosome 7q11.23. We find that variation in the transcript levels of the brain gene STX1A correlates significantly with intelligence in WS patients measured by principal component analysis (PCA) of standardized WAIS-R subtests, r = 0.40 (Pearson correlation, Bonferroni corrected p-value = 0.007), accounting for 15.6% of the cognitive variation. These results suggest that syntaxin 1A, a neuronal regulator of presynaptic vesicle release, may play a role in WS and be a component of the cellular pathway determining human intelligence. |
format | Text |
id | pubmed-2858212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28582122010-04-26 Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex Gao, Michael C. Bellugi, Ursula Dai, Li Mills, Debra L. Sobel, Eric M. Lange, Kenneth Korenberg, Julie R. PLoS One Research Article Although genetics is the most significant known determinant of human intelligence, specific gene contributions remain largely unknown. To accelerate understanding in this area, we have taken a new approach by studying the relationship between quantitative gene expression and intelligence in a cohort of 65 patients with Williams Syndrome (WS), a neurodevelopmental disorder caused by a 1.5 Mb deletion on chromosome 7q11.23. We find that variation in the transcript levels of the brain gene STX1A correlates significantly with intelligence in WS patients measured by principal component analysis (PCA) of standardized WAIS-R subtests, r = 0.40 (Pearson correlation, Bonferroni corrected p-value = 0.007), accounting for 15.6% of the cognitive variation. These results suggest that syntaxin 1A, a neuronal regulator of presynaptic vesicle release, may play a role in WS and be a component of the cellular pathway determining human intelligence. Public Library of Science 2010-04-21 /pmc/articles/PMC2858212/ /pubmed/20422020 http://dx.doi.org/10.1371/journal.pone.0010292 Text en Gao et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Gao, Michael C. Bellugi, Ursula Dai, Li Mills, Debra L. Sobel, Eric M. Lange, Kenneth Korenberg, Julie R. Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex |
title | Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex |
title_full | Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex |
title_fullStr | Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex |
title_full_unstemmed | Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex |
title_short | Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex |
title_sort | intelligence in williams syndrome is related to stx1a, which encodes a component of the presynaptic snare complex |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858212/ https://www.ncbi.nlm.nih.gov/pubmed/20422020 http://dx.doi.org/10.1371/journal.pone.0010292 |
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