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PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
Peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in atherogenesis. The activation of PPARγ1 and LXRα by natural or synthetic ligands resu...
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Formato: | Texto |
Lenguaje: | English |
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The Nuclear Receptor Signaling Atlas
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858268/ https://www.ncbi.nlm.nih.gov/pubmed/20419060 http://dx.doi.org/10.1621/nrs.08004 |
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author | Majdalawieh, Amin Ro, Hyo-Sung |
author_facet | Majdalawieh, Amin Ro, Hyo-Sung |
author_sort | Majdalawieh, Amin |
collection | PubMed |
description | Peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in atherogenesis. The activation of PPARγ1 and LXRα by natural or synthetic ligands results in the transactivation of ABCA1, ABCG1, and ApoE; integral players in cholesterol efflux and reverse cholesterol transport. In this review, we describe the structure, isoforms, expression pattern, and functional specificity of PPARs and LXRs. Control of PPARs and LXRs transcriptional activity by coactivators and corepressors is also highlighted. The specific roles that PPARγ1 and LXRα play in inducing macrophage cholesterol efflux mediators and antagonizing macrophage inflammatory responsiveness are summarized. Finally, this review focuses on the recently reported regulatory functions that adipocyte enhancer-binding protein 1 (AEBP1) exerts on PPARγ1 and LXRα transcriptional activity in the context of macrophage cholesterol homeostasis and inflammation. |
format | Text |
id | pubmed-2858268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Nuclear Receptor Signaling Atlas |
record_format | MEDLINE/PubMed |
spelling | pubmed-28582682010-04-23 PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 Majdalawieh, Amin Ro, Hyo-Sung Nucl Recept Signal Review Peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in atherogenesis. The activation of PPARγ1 and LXRα by natural or synthetic ligands results in the transactivation of ABCA1, ABCG1, and ApoE; integral players in cholesterol efflux and reverse cholesterol transport. In this review, we describe the structure, isoforms, expression pattern, and functional specificity of PPARs and LXRs. Control of PPARs and LXRs transcriptional activity by coactivators and corepressors is also highlighted. The specific roles that PPARγ1 and LXRα play in inducing macrophage cholesterol efflux mediators and antagonizing macrophage inflammatory responsiveness are summarized. Finally, this review focuses on the recently reported regulatory functions that adipocyte enhancer-binding protein 1 (AEBP1) exerts on PPARγ1 and LXRα transcriptional activity in the context of macrophage cholesterol homeostasis and inflammation. The Nuclear Receptor Signaling Atlas 2010-04-16 /pmc/articles/PMC2858268/ /pubmed/20419060 http://dx.doi.org/10.1621/nrs.08004 Text en Copyright © 2010, Majdalawieh and Ro. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Majdalawieh, Amin Ro, Hyo-Sung PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 |
title | PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 |
title_full | PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 |
title_fullStr | PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 |
title_full_unstemmed | PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 |
title_short | PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 |
title_sort | pparγ1 and lxrα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, aebp1 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858268/ https://www.ncbi.nlm.nih.gov/pubmed/20419060 http://dx.doi.org/10.1621/nrs.08004 |
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