Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO-1) in some situations results in cell death and in others leads to the activation of NF-κB. We established an integrated kinetic mathematical model for CD95-mediated apoptotic and NF-κB signaling. Systematic model...

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Detalles Bibliográficos
Autores principales: Neumann, Leo, Pforr, Carina, Beaudouin, Joel, Pappa, Alexander, Fricker, Nicolai, Krammer, Peter H, Lavrik, Inna N, Eils, Roland
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858442/
https://www.ncbi.nlm.nih.gov/pubmed/20212524
http://dx.doi.org/10.1038/msb.2010.6

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