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Impact of RNA Editing on Functions of the Serotonin 2C Receptor in vivo

Transcripts encoding 5-HT(2C) receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5-HT(2C-VGV), exhibits blunted G-protein coupling and reduced constitutive activity. The present studies examine the signal...

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Detalles Bibliográficos
Autores principales:	Olaghere da Silva, Uade B., Morabito, Michael V., Canal, Clinton E., Airey, David C., Emeson, Ronald B., Sanders-Bush, Elaine
Formato:	Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2010
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858556/ https://www.ncbi.nlm.nih.gov/pubmed/20582266 http://dx.doi.org/10.3389/neuro.23.001.2010

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