Cdh11 Acts as a Tumor Suppressor in a Murine Retinoblastoma Model by Facilitating Tumor Cell Death

CDH11 gene copy number and expression are frequently lost in human retinoblastomas and in retinoblastomas arising in TAg-RB mice. To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with TAg-RB mice. Loss of Cdh11 had no gross morphological effect on the developing ret...

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Detalles Bibliográficos
Autores principales: Marchong, Mellone N., Yurkowski, Christine, Ma, Clement, Spencer, Clarellen, Pajovic, Sanja, Gallie, Brenda L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858707/
https://www.ncbi.nlm.nih.gov/pubmed/20421947
http://dx.doi.org/10.1371/journal.pgen.1000923

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