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Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model
The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents w...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858830/ https://www.ncbi.nlm.nih.gov/pubmed/20436707 http://dx.doi.org/10.3346/jkms.2010.25.5.716 |
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author | Cho, Jung Sun Jeong, Myung Ho Sim, Doo Sun Hong, Young Joon Lim, Kyung Seob Kim, Jung Ha Kim, Hyoung Doo Baek, Ju Yeal Yoon, Hee Jeoung Her, Sung-Ho Jin, Seung Won Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee |
author_facet | Cho, Jung Sun Jeong, Myung Ho Sim, Doo Sun Hong, Young Joon Lim, Kyung Seob Kim, Jung Ha Kim, Hyoung Doo Baek, Ju Yeal Yoon, Hee Jeoung Her, Sung-Ho Jin, Seung Won Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee |
author_sort | Cho, Jung Sun |
collection | PubMed |
description | The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents were deployed with oversizing (stent/artery ratio 1.3:1) in porcine coronary arteries. Fifteen pigs were taken 10/20 mg of E/S and eight pigs were not taken E/S. Histopathologic analysis was assessed at 28 days after stenting. In neointima, most inflammatory cells were lymphohistiocytes. Lymphohistiocyte count was not different between two groups (337±227 vs. 443±366 cells, P=0.292), but neointima area was significantly smaller (1.00±0.49 mm(2) vs. 1.69±0.98 mm(2), P=0.021) and percent area stenosis was significantly lower (23.3±10% vs. 39±19%, P=0.007) in E/S group compared with control group. There were no significant differences in fibrin score (1.99±0.79 vs. 1.81±0.88, P=0.49), endothelial score (1.75±0.66 vs. 1.80±0.59, P=0.79), and the percent of endothelium covered lumen (43±21% vs. 45±21%, P=0.84) between E/S group and control group. Combined therapy with ezetimibe and simvastatin inhibits neointimal hyperplasia, but does not inhibit inflammatory infiltration and arterial healing after DES implantation in a porcine coronary restenosis model. |
format | Text |
id | pubmed-2858830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-28588302010-05-01 Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model Cho, Jung Sun Jeong, Myung Ho Sim, Doo Sun Hong, Young Joon Lim, Kyung Seob Kim, Jung Ha Kim, Hyoung Doo Baek, Ju Yeal Yoon, Hee Jeoung Her, Sung-Ho Jin, Seung Won Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee J Korean Med Sci Original Article The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents were deployed with oversizing (stent/artery ratio 1.3:1) in porcine coronary arteries. Fifteen pigs were taken 10/20 mg of E/S and eight pigs were not taken E/S. Histopathologic analysis was assessed at 28 days after stenting. In neointima, most inflammatory cells were lymphohistiocytes. Lymphohistiocyte count was not different between two groups (337±227 vs. 443±366 cells, P=0.292), but neointima area was significantly smaller (1.00±0.49 mm(2) vs. 1.69±0.98 mm(2), P=0.021) and percent area stenosis was significantly lower (23.3±10% vs. 39±19%, P=0.007) in E/S group compared with control group. There were no significant differences in fibrin score (1.99±0.79 vs. 1.81±0.88, P=0.49), endothelial score (1.75±0.66 vs. 1.80±0.59, P=0.79), and the percent of endothelium covered lumen (43±21% vs. 45±21%, P=0.84) between E/S group and control group. Combined therapy with ezetimibe and simvastatin inhibits neointimal hyperplasia, but does not inhibit inflammatory infiltration and arterial healing after DES implantation in a porcine coronary restenosis model. The Korean Academy of Medical Sciences 2010-05 2010-04-16 /pmc/articles/PMC2858830/ /pubmed/20436707 http://dx.doi.org/10.3346/jkms.2010.25.5.716 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cho, Jung Sun Jeong, Myung Ho Sim, Doo Sun Hong, Young Joon Lim, Kyung Seob Kim, Jung Ha Kim, Hyoung Doo Baek, Ju Yeal Yoon, Hee Jeoung Her, Sung-Ho Jin, Seung Won Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model |
title | Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model |
title_full | Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model |
title_fullStr | Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model |
title_full_unstemmed | Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model |
title_short | Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model |
title_sort | effects of combined therapy with ezetimibe plus simvastatin after drug-eluting stent implantation in a porcine coronary restenosis model |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858830/ https://www.ncbi.nlm.nih.gov/pubmed/20436707 http://dx.doi.org/10.3346/jkms.2010.25.5.716 |
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