Hematopoietic Stem Cell Transplantation after Posttransplant Lymphoproliferative Disorder

A 16-yr-old girl received liver transplantation for fulminant hepatitis. Aplastic anemia developed, and she received hematopoietic stem cell transplantation (HSCT). Eleven months after liver transplantation, abdominal lymph node enlargement and colon ulcers were observed, and colon biopsy showed pos...

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Detalles Bibliográficos
Autores principales: Kim, Min Joo, Kim, Inho, Bae, Hyun-Mi, Seo, Kyungsuk, Park, Namjun, Yoon, Sung-Soo, Park, Seonyang, Kim, Byoung Kook
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858841/
https://www.ncbi.nlm.nih.gov/pubmed/20436718
http://dx.doi.org/10.3346/jkms.2010.25.5.781
Descripción
Sumario:A 16-yr-old girl received liver transplantation for fulminant hepatitis. Aplastic anemia developed, and she received hematopoietic stem cell transplantation (HSCT). Eleven months after liver transplantation, abdominal lymph node enlargement and colon ulcers were observed, and colon biopsy showed posttransplant lymphoproliferative disorder (PTLD). Immunosuppression reduction was attempted, but it produced no therapeutic effect. Fourteen months after liver transplantation, she received a second HSCT due to engraftment failure, and PTLD resolved completely. The second HSCT can serve as cellular therapy for PTLD.

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