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Retrospective Study of Salinomycin Toxicosis in 66 Cats

We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological...

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Autores principales: Pakozdy, Akos, Challande-Kathman, Iris, Doherr, Marcus, Cizinauskas, Sigitas, Wheeler, Simon J., Oevermann, Anna, Jaggy, Andre
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859021/
https://www.ncbi.nlm.nih.gov/pubmed/20445777
http://dx.doi.org/10.4061/2010/147142
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author Pakozdy, Akos
Challande-Kathman, Iris
Doherr, Marcus
Cizinauskas, Sigitas
Wheeler, Simon J.
Oevermann, Anna
Jaggy, Andre
author_facet Pakozdy, Akos
Challande-Kathman, Iris
Doherr, Marcus
Cizinauskas, Sigitas
Wheeler, Simon J.
Oevermann, Anna
Jaggy, Andre
author_sort Pakozdy, Akos
collection PubMed
description We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10 cases, motor nerve conductance velocity was mildly decreased in 8/12 cats, and sensory nerve conductance velocity and repetitive nerve stimulation were normal in all examined cases. In five cases the peripheral neuropathy was confirmed by pathohistology. Fluid therapy and supportive care were used as therapy and 52 cats recovered completely. The probability for complete remission was significantly different between mildly and severely affected cases. It seems that the severity of clinical signs and prognosis correlate well with the amount of toxin ingested. We conclude that early recognition and decontamination combined with supportive care results in complete recovery.
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spelling pubmed-28590212010-05-05 Retrospective Study of Salinomycin Toxicosis in 66 Cats Pakozdy, Akos Challande-Kathman, Iris Doherr, Marcus Cizinauskas, Sigitas Wheeler, Simon J. Oevermann, Anna Jaggy, Andre Vet Med Int Research Article We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10 cases, motor nerve conductance velocity was mildly decreased in 8/12 cats, and sensory nerve conductance velocity and repetitive nerve stimulation were normal in all examined cases. In five cases the peripheral neuropathy was confirmed by pathohistology. Fluid therapy and supportive care were used as therapy and 52 cats recovered completely. The probability for complete remission was significantly different between mildly and severely affected cases. It seems that the severity of clinical signs and prognosis correlate well with the amount of toxin ingested. We conclude that early recognition and decontamination combined with supportive care results in complete recovery. SAGE-Hindawi Access to Research 2010-03-22 /pmc/articles/PMC2859021/ /pubmed/20445777 http://dx.doi.org/10.4061/2010/147142 Text en Copyright © 2010 Akos Pakozdy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pakozdy, Akos
Challande-Kathman, Iris
Doherr, Marcus
Cizinauskas, Sigitas
Wheeler, Simon J.
Oevermann, Anna
Jaggy, Andre
Retrospective Study of Salinomycin Toxicosis in 66 Cats
title Retrospective Study of Salinomycin Toxicosis in 66 Cats
title_full Retrospective Study of Salinomycin Toxicosis in 66 Cats
title_fullStr Retrospective Study of Salinomycin Toxicosis in 66 Cats
title_full_unstemmed Retrospective Study of Salinomycin Toxicosis in 66 Cats
title_short Retrospective Study of Salinomycin Toxicosis in 66 Cats
title_sort retrospective study of salinomycin toxicosis in 66 cats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859021/
https://www.ncbi.nlm.nih.gov/pubmed/20445777
http://dx.doi.org/10.4061/2010/147142
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