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Retinoblastoma and the Genetic Theory of Cancer: An Old Paradigm Trying to Survive to the Evidence
Retinoblastoma (Rb) is considered to represent the prototype of cancer linked to the sequential loss or inactivation of both alleles of a so-called “tumor suppressor gene”, the Rb1 gene. The pathogenetic mechanism behind this tumor was first hypothesized by Knudson in 1971 and further confirmed by o...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859046/ https://www.ncbi.nlm.nih.gov/pubmed/20445799 http://dx.doi.org/10.1155/2009/301973 |