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Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy

High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with e...

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Autores principales: Jiruska, Premysl, Finnerty, Gerald T., Powell, Andrew D., Lofti, Noosheen, Cmejla, Roman, Jefferys, John G. R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859153/
https://www.ncbi.nlm.nih.gov/pubmed/20400525
http://dx.doi.org/10.1093/brain/awq070
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author Jiruska, Premysl
Finnerty, Gerald T.
Powell, Andrew D.
Lofti, Noosheen
Cmejla, Roman
Jefferys, John G. R.
author_facet Jiruska, Premysl
Finnerty, Gerald T.
Powell, Andrew D.
Lofti, Noosheen
Cmejla, Roman
Jefferys, John G. R.
author_sort Jiruska, Premysl
collection PubMed
description High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (>100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100–250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy.
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spelling pubmed-28591532010-04-26 Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy Jiruska, Premysl Finnerty, Gerald T. Powell, Andrew D. Lofti, Noosheen Cmejla, Roman Jefferys, John G. R. Brain Original Articles High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (>100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100–250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy. Oxford University Press 2010-05 2010-04-16 /pmc/articles/PMC2859153/ /pubmed/20400525 http://dx.doi.org/10.1093/brain/awq070 Text en © The Author(s) 2010. Published by Oxford University Press on behalf of Brain. http://creativecommons.org/licenses/by-nc/2.5 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Jiruska, Premysl
Finnerty, Gerald T.
Powell, Andrew D.
Lofti, Noosheen
Cmejla, Roman
Jefferys, John G. R.
Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
title Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
title_full Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
title_fullStr Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
title_full_unstemmed Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
title_short Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
title_sort epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859153/
https://www.ncbi.nlm.nih.gov/pubmed/20400525
http://dx.doi.org/10.1093/brain/awq070
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