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Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance

Mutations in the fmt gene (encoding formyl methionine transferase) that eliminate formylation of initiator tRNA (Met-tRNA(i)) confer resistance to the novel antibiotic class of peptide deformylase inhibitors (PDFIs) while concomitantly reducing bacterial fitness. Here we show in Salmonella typhimuri...

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Detalles Bibliográficos
Autores principales:	Zorzet, Anna, Pavlov, Michael Y, Nilsson, Annika I, Ehrenberg, Måns, Andersson, Dan I
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859245/ https://www.ncbi.nlm.nih.gov/pubmed/20132454 http://dx.doi.org/10.1111/j.1365-2958.2010.07057.x

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