Significantly increased levels of serum malonaldehyde in type 2 diabetics with myocardial infarction

AIM/OBJECTIVE: To see the levels of serum MDA in type 2 DM with MI. As Serum malonaldeyhde (MDA), a stable end product of lipid per oxidation produced by interaction of free radicals with membrane phospholipids, was estimated. MATERIALS AND METHODS: 30 type 2 diabetes mellitus cases with myocardial infarction and equal members of Type 2 diabetics without complications are enrolled. Thirty healthy subjects served as controls. Quantitative estimation of serum MDA levels were carried out in all the three groups, along with fasting blood glucose and total serum cholesterol. RESULTS: It was found that serum MDA levels were significantly higher in both diabetic groups compare to the controls (P<0.01). Within the diabetic group, the serum MDA levels were significantly high in patients with myocardial infarction (P<0.01). CONCLUSION: The possible reason for significantly high serum MDA levels in cases of diabetic with myocardial infarction is due to tissue damage caused by myocardial infarction resulting in increased rate of production of free radicals as assessed by lipid per oxidation.