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Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women

BACKGROUND: Previous epidemiological investigations of associations between dietary glycemic intake and insulin resistance have used average daily measures of glycemic index (GI) and glycemic load (GL). We explored multiple and novel measures of dietary glycemic intake to determine which was most pr...

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Autores principales: O'Sullivan, Therese A, Bremner, Alexandra P, O'Neill, Sheila, Lyons-Wall, Philippa
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859357/
https://www.ncbi.nlm.nih.gov/pubmed/20370933
http://dx.doi.org/10.1186/1743-7075-7-25
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author O'Sullivan, Therese A
Bremner, Alexandra P
O'Neill, Sheila
Lyons-Wall, Philippa
author_facet O'Sullivan, Therese A
Bremner, Alexandra P
O'Neill, Sheila
Lyons-Wall, Philippa
author_sort O'Sullivan, Therese A
collection PubMed
description BACKGROUND: Previous epidemiological investigations of associations between dietary glycemic intake and insulin resistance have used average daily measures of glycemic index (GI) and glycemic load (GL). We explored multiple and novel measures of dietary glycemic intake to determine which was most predictive of an association with insulin resistance. METHODS: Usual dietary intakes were assessed by diet history interview in women aged 42-81 years participating in the Longitudinal Assessment of Ageing in Women. Daily measures of dietary glycemic intake (n = 329) were carbohydrate, GI, GL, and GL per megacalorie (GL/Mcal), while meal based measures (n = 200) were breakfast, lunch and dinner GL; and a new measure, GL peak score, to represent meal peaks. Insulin resistant status was defined as a homeostasis model assessment (HOMA) value of >3.99; HOMA as a continuous variable was also investigated. RESULTS: GL, GL/Mcal, carbohydrate (all P < 0.01), GL peak score (P = 0.04) and lunch GL (P = 0.04) were positively and independently associated with insulin resistant status. Daily measures were more predictive than meal-based measures, with minimal difference between GL/Mcal, GL and carbohydrate. No significant associations were observed with HOMA as a continuous variable. CONCLUSION: A dietary pattern with high peaks of GL above the individual's average intake was a significant independent predictor of insulin resistance in this population, however the contribution was less than daily GL and carbohydrate variables. Accounting for energy intake slightly increased the predictive ability of GL, which is potentially important when examining disease risk in more diverse populations with wider variations in energy requirements.
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spelling pubmed-28593572010-04-27 Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women O'Sullivan, Therese A Bremner, Alexandra P O'Neill, Sheila Lyons-Wall, Philippa Nutr Metab (Lond) Research BACKGROUND: Previous epidemiological investigations of associations between dietary glycemic intake and insulin resistance have used average daily measures of glycemic index (GI) and glycemic load (GL). We explored multiple and novel measures of dietary glycemic intake to determine which was most predictive of an association with insulin resistance. METHODS: Usual dietary intakes were assessed by diet history interview in women aged 42-81 years participating in the Longitudinal Assessment of Ageing in Women. Daily measures of dietary glycemic intake (n = 329) were carbohydrate, GI, GL, and GL per megacalorie (GL/Mcal), while meal based measures (n = 200) were breakfast, lunch and dinner GL; and a new measure, GL peak score, to represent meal peaks. Insulin resistant status was defined as a homeostasis model assessment (HOMA) value of >3.99; HOMA as a continuous variable was also investigated. RESULTS: GL, GL/Mcal, carbohydrate (all P < 0.01), GL peak score (P = 0.04) and lunch GL (P = 0.04) were positively and independently associated with insulin resistant status. Daily measures were more predictive than meal-based measures, with minimal difference between GL/Mcal, GL and carbohydrate. No significant associations were observed with HOMA as a continuous variable. CONCLUSION: A dietary pattern with high peaks of GL above the individual's average intake was a significant independent predictor of insulin resistance in this population, however the contribution was less than daily GL and carbohydrate variables. Accounting for energy intake slightly increased the predictive ability of GL, which is potentially important when examining disease risk in more diverse populations with wider variations in energy requirements. BioMed Central 2010-04-07 /pmc/articles/PMC2859357/ /pubmed/20370933 http://dx.doi.org/10.1186/1743-7075-7-25 Text en Copyright ©2010 O'Sullivan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
O'Sullivan, Therese A
Bremner, Alexandra P
O'Neill, Sheila
Lyons-Wall, Philippa
Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women
title Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women
title_full Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women
title_fullStr Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women
title_full_unstemmed Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women
title_short Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women
title_sort comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859357/
https://www.ncbi.nlm.nih.gov/pubmed/20370933
http://dx.doi.org/10.1186/1743-7075-7-25
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