CFP: a web­server for constructing sequence­based protein conformational flexibility profiles

Many proteins contain conformationally flexible segments that undergo significant changes in the backbone conformation or completely lack a well­defined conformation. Previously, we have developed the generalized local propensity (GLP), a quantitative sequence-based measure of the protein backbone f...

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Detalles Bibliográficos
Autores principales: Kuznetsov, Igor B, Rackovsky, Shalom
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2009
Materias:
Web Server
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859570/
https://www.ncbi.nlm.nih.gov/pubmed/20461153
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author Kuznetsov, Igor B
Rackovsky, Shalom
author_facet Kuznetsov, Igor B
Rackovsky, Shalom
author_sort Kuznetsov, Igor B
collection PubMed
description Many proteins contain conformationally flexible segments that undergo significant changes in the backbone conformation or completely lack a well­defined conformation. Previously, we have developed the generalized local propensity (GLP), a quantitative sequence-based measure of the protein backbone flexibility. In this paper, we present the CFP (Conformational Flexibility Profile) web­server that constructs the GLP flexibility profile for a user­submitted sequence and uses this profile to identify segments with high backbone flexibility. The statistical significance of a flexible sequence segment is assessed using the discrete scan statistics based on the density of flexible residues observed in this segment. AVAILABILITY: CFP is publicly available at http://cfp.rit.albany.edu
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spelling pubmed-28595702010-05-11 CFP: a web­server for constructing sequence­based protein conformational flexibility profiles Kuznetsov, Igor B Rackovsky, Shalom Bioinformation Web Server Many proteins contain conformationally flexible segments that undergo significant changes in the backbone conformation or completely lack a well­defined conformation. Previously, we have developed the generalized local propensity (GLP), a quantitative sequence-based measure of the protein backbone flexibility. In this paper, we present the CFP (Conformational Flexibility Profile) web­server that constructs the GLP flexibility profile for a user­submitted sequence and uses this profile to identify segments with high backbone flexibility. The statistical significance of a flexible sequence segment is assessed using the discrete scan statistics based on the density of flexible residues observed in this segment. AVAILABILITY: CFP is publicly available at http://cfp.rit.albany.edu Biomedical Informatics Publishing Group 2009-10-19 /pmc/articles/PMC2859570/ /pubmed/20461153 Text en © 2009 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Web Server
Kuznetsov, Igor B
Rackovsky, Shalom
CFP: a web­server for constructing sequence­based protein conformational flexibility profiles
title CFP: a web­server for constructing sequence­based protein conformational flexibility profiles
title_full CFP: a web­server for constructing sequence­based protein conformational flexibility profiles
title_fullStr CFP: a web­server for constructing sequence­based protein conformational flexibility profiles
title_full_unstemmed CFP: a web­server for constructing sequence­based protein conformational flexibility profiles
title_short CFP: a web­server for constructing sequence­based protein conformational flexibility profiles
title_sort cfp: a web­server for constructing sequence­based protein conformational flexibility profiles
topic Web Server
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859570/
https://www.ncbi.nlm.nih.gov/pubmed/20461153
work_keys_str_mv AT kuznetsovigorb cfpawebserverforconstructingsequencebasedproteinconformationalflexibilityprofiles
AT rackovskyshalom cfpawebserverforconstructingsequencebasedproteinconformationalflexibilityprofiles

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