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NeuronBank: A Tool for Cataloging Neuronal Circuitry
The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in ma...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859812/ https://www.ncbi.nlm.nih.gov/pubmed/20428500 http://dx.doi.org/10.3389/fnsys.2010.00009 |
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author | Katz, Paul S. Calin-Jageman, Robert Dhawan, Akshaye Frederick, Chad Guo, Shuman Dissanayaka, Rasanjalee Hiremath, Naveen Ma, Wenjun Shen, Xiuyn Wang, Hsui C. Yang, Hong Prasad, Sushil Sunderraman, Rajshekhar Zhu, Ying |
author_facet | Katz, Paul S. Calin-Jageman, Robert Dhawan, Akshaye Frederick, Chad Guo, Shuman Dissanayaka, Rasanjalee Hiremath, Naveen Ma, Wenjun Shen, Xiuyn Wang, Hsui C. Yang, Hong Prasad, Sushil Sunderraman, Rajshekhar Zhu, Ying |
author_sort | Katz, Paul S. |
collection | PubMed |
description | The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in many invertebrates has facilitated the construction of cellular-level connectivity diagrams that can be generalized across individuals within a species. Homologous neurons can also be recognized across species. Here we describe NeuronBank.org, a web-based tool that we are developing for cataloging, searching, and analyzing neuronal circuitry within and across species. Information from a single species is represented in an individual branch of NeuronBank. Users can search within a branch or perform queries across branches to look for similarities in neuronal circuits across species. The branches allow for an extensible ontology so that additional characteristics can be added as knowledge grows. Each entry in NeuronBank generates a unique accession ID, allowing it to be easily cited. There is also an automatic link to a Wiki page allowing an encyclopedic explanation of the entry. All of the 44 previously published neurons plus one previously unpublished neuron from the mollusc, Tritonia diomedea, have been entered into a branch of NeuronBank as have 4 previously published neurons from the mollusc, Melibe leonina. The ability to organize information about neuronal circuits will make this information more accessible, ultimately aiding research on these important models. |
format | Text |
id | pubmed-2859812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28598122010-04-27 NeuronBank: A Tool for Cataloging Neuronal Circuitry Katz, Paul S. Calin-Jageman, Robert Dhawan, Akshaye Frederick, Chad Guo, Shuman Dissanayaka, Rasanjalee Hiremath, Naveen Ma, Wenjun Shen, Xiuyn Wang, Hsui C. Yang, Hong Prasad, Sushil Sunderraman, Rajshekhar Zhu, Ying Front Syst Neurosci Neuroscience The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in many invertebrates has facilitated the construction of cellular-level connectivity diagrams that can be generalized across individuals within a species. Homologous neurons can also be recognized across species. Here we describe NeuronBank.org, a web-based tool that we are developing for cataloging, searching, and analyzing neuronal circuitry within and across species. Information from a single species is represented in an individual branch of NeuronBank. Users can search within a branch or perform queries across branches to look for similarities in neuronal circuits across species. The branches allow for an extensible ontology so that additional characteristics can be added as knowledge grows. Each entry in NeuronBank generates a unique accession ID, allowing it to be easily cited. There is also an automatic link to a Wiki page allowing an encyclopedic explanation of the entry. All of the 44 previously published neurons plus one previously unpublished neuron from the mollusc, Tritonia diomedea, have been entered into a branch of NeuronBank as have 4 previously published neurons from the mollusc, Melibe leonina. The ability to organize information about neuronal circuits will make this information more accessible, ultimately aiding research on these important models. Frontiers Research Foundation 2010-04-19 /pmc/articles/PMC2859812/ /pubmed/20428500 http://dx.doi.org/10.3389/fnsys.2010.00009 Text en Copyright © 2009 Katz, Calin-Jageman, Dhawan, Frederick, Guo, Dissanayaka, Hiremath, Ma, Shen, Wang, Yang, Prasad, Sunderraman and Zhu. http://www.frontiersin.org/licenseagreement This is an open-access publication subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Katz, Paul S. Calin-Jageman, Robert Dhawan, Akshaye Frederick, Chad Guo, Shuman Dissanayaka, Rasanjalee Hiremath, Naveen Ma, Wenjun Shen, Xiuyn Wang, Hsui C. Yang, Hong Prasad, Sushil Sunderraman, Rajshekhar Zhu, Ying NeuronBank: A Tool for Cataloging Neuronal Circuitry |
title | NeuronBank: A Tool for Cataloging Neuronal Circuitry |
title_full | NeuronBank: A Tool for Cataloging Neuronal Circuitry |
title_fullStr | NeuronBank: A Tool for Cataloging Neuronal Circuitry |
title_full_unstemmed | NeuronBank: A Tool for Cataloging Neuronal Circuitry |
title_short | NeuronBank: A Tool for Cataloging Neuronal Circuitry |
title_sort | neuronbank: a tool for cataloging neuronal circuitry |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859812/ https://www.ncbi.nlm.nih.gov/pubmed/20428500 http://dx.doi.org/10.3389/fnsys.2010.00009 |
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