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NeuronBank: A Tool for Cataloging Neuronal Circuitry

The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in ma...

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Autores principales: Katz, Paul S., Calin-Jageman, Robert, Dhawan, Akshaye, Frederick, Chad, Guo, Shuman, Dissanayaka, Rasanjalee, Hiremath, Naveen, Ma, Wenjun, Shen, Xiuyn, Wang, Hsui C., Yang, Hong, Prasad, Sushil, Sunderraman, Rajshekhar, Zhu, Ying
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859812/
https://www.ncbi.nlm.nih.gov/pubmed/20428500
http://dx.doi.org/10.3389/fnsys.2010.00009
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author Katz, Paul S.
Calin-Jageman, Robert
Dhawan, Akshaye
Frederick, Chad
Guo, Shuman
Dissanayaka, Rasanjalee
Hiremath, Naveen
Ma, Wenjun
Shen, Xiuyn
Wang, Hsui C.
Yang, Hong
Prasad, Sushil
Sunderraman, Rajshekhar
Zhu, Ying
author_facet Katz, Paul S.
Calin-Jageman, Robert
Dhawan, Akshaye
Frederick, Chad
Guo, Shuman
Dissanayaka, Rasanjalee
Hiremath, Naveen
Ma, Wenjun
Shen, Xiuyn
Wang, Hsui C.
Yang, Hong
Prasad, Sushil
Sunderraman, Rajshekhar
Zhu, Ying
author_sort Katz, Paul S.
collection PubMed
description The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in many invertebrates has facilitated the construction of cellular-level connectivity diagrams that can be generalized across individuals within a species. Homologous neurons can also be recognized across species. Here we describe NeuronBank.org, a web-based tool that we are developing for cataloging, searching, and analyzing neuronal circuitry within and across species. Information from a single species is represented in an individual branch of NeuronBank. Users can search within a branch or perform queries across branches to look for similarities in neuronal circuits across species. The branches allow for an extensible ontology so that additional characteristics can be added as knowledge grows. Each entry in NeuronBank generates a unique accession ID, allowing it to be easily cited. There is also an automatic link to a Wiki page allowing an encyclopedic explanation of the entry. All of the 44 previously published neurons plus one previously unpublished neuron from the mollusc, Tritonia diomedea, have been entered into a branch of NeuronBank as have 4 previously published neurons from the mollusc, Melibe leonina. The ability to organize information about neuronal circuits will make this information more accessible, ultimately aiding research on these important models.
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spelling pubmed-28598122010-04-27 NeuronBank: A Tool for Cataloging Neuronal Circuitry Katz, Paul S. Calin-Jageman, Robert Dhawan, Akshaye Frederick, Chad Guo, Shuman Dissanayaka, Rasanjalee Hiremath, Naveen Ma, Wenjun Shen, Xiuyn Wang, Hsui C. Yang, Hong Prasad, Sushil Sunderraman, Rajshekhar Zhu, Ying Front Syst Neurosci Neuroscience The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in many invertebrates has facilitated the construction of cellular-level connectivity diagrams that can be generalized across individuals within a species. Homologous neurons can also be recognized across species. Here we describe NeuronBank.org, a web-based tool that we are developing for cataloging, searching, and analyzing neuronal circuitry within and across species. Information from a single species is represented in an individual branch of NeuronBank. Users can search within a branch or perform queries across branches to look for similarities in neuronal circuits across species. The branches allow for an extensible ontology so that additional characteristics can be added as knowledge grows. Each entry in NeuronBank generates a unique accession ID, allowing it to be easily cited. There is also an automatic link to a Wiki page allowing an encyclopedic explanation of the entry. All of the 44 previously published neurons plus one previously unpublished neuron from the mollusc, Tritonia diomedea, have been entered into a branch of NeuronBank as have 4 previously published neurons from the mollusc, Melibe leonina. The ability to organize information about neuronal circuits will make this information more accessible, ultimately aiding research on these important models. Frontiers Research Foundation 2010-04-19 /pmc/articles/PMC2859812/ /pubmed/20428500 http://dx.doi.org/10.3389/fnsys.2010.00009 Text en Copyright © 2009 Katz, Calin-Jageman, Dhawan, Frederick, Guo, Dissanayaka, Hiremath, Ma, Shen, Wang, Yang, Prasad, Sunderraman and Zhu. http://www.frontiersin.org/licenseagreement This is an open-access publication subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Katz, Paul S.
Calin-Jageman, Robert
Dhawan, Akshaye
Frederick, Chad
Guo, Shuman
Dissanayaka, Rasanjalee
Hiremath, Naveen
Ma, Wenjun
Shen, Xiuyn
Wang, Hsui C.
Yang, Hong
Prasad, Sushil
Sunderraman, Rajshekhar
Zhu, Ying
NeuronBank: A Tool for Cataloging Neuronal Circuitry
title NeuronBank: A Tool for Cataloging Neuronal Circuitry
title_full NeuronBank: A Tool for Cataloging Neuronal Circuitry
title_fullStr NeuronBank: A Tool for Cataloging Neuronal Circuitry
title_full_unstemmed NeuronBank: A Tool for Cataloging Neuronal Circuitry
title_short NeuronBank: A Tool for Cataloging Neuronal Circuitry
title_sort neuronbank: a tool for cataloging neuronal circuitry
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859812/
https://www.ncbi.nlm.nih.gov/pubmed/20428500
http://dx.doi.org/10.3389/fnsys.2010.00009
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