Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase

BACKGROUND: During the early stage of HIV-1 replication, integrase (IN) plays important roles at several steps, including reverse transcription, viral DNA nuclear import, targeting viral DNA to host chromatin and integration. Previous studies have demonstrated that HIV-1 IN interacts with a cellular...

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Detalles Bibliográficos
Autores principales: Zheng, Yingfeng, Ao, Zhujun, Jayappa, Kallesh Danappa, Yao, Xiaojian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859858/
https://www.ncbi.nlm.nih.gov/pubmed/20331877
http://dx.doi.org/10.1186/1743-422X-7-68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859858/
https://www.ncbi.nlm.nih.gov/pubmed/20331877
http://dx.doi.org/10.1186/1743-422X-7-68

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