The HIV-1 Integrase Mutations Y143C/R Are an Alternative Pathway for Resistance to Raltegravir and Impact the Enzyme Functions

Resistance to HIV-1 integrase (IN) inhibitor raltegravir (RAL), is encoded by mutations in the IN region of the pol gene. The emergence of the N155H mutation was replaced by a pattern including the Y143R/C/H mutations in three patients with anti-HIV treatment failure. Cloning analysis of the IN gene...

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Detalles Bibliográficos
Autores principales: Reigadas, Sandrine, Anies, Guerric, Masquelier, Bernard, Calmels, Christina, Stuyver, Lieven J., Parissi, Vincent, Fleury, Herve, Andreola, Marie-Line
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859942/
https://www.ncbi.nlm.nih.gov/pubmed/20436677
http://dx.doi.org/10.1371/journal.pone.0010311

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