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Transfer of ion binding site from ether-à-go-go to Shaker: Mg(2+) binds to resting state to modulate channel opening
In ether-à-go-go (eag) K(+) channels, extracellular divalent cations bind to the resting voltage sensor and thereby slow activation. Two eag-specific acidic residues in S2 and S3b coordinate the bound ion. Residues located at analogous positions are ∼4 Å apart in the x-ray structure of a Kv1.2/Kv2.1...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860588/ https://www.ncbi.nlm.nih.gov/pubmed/20385745 http://dx.doi.org/10.1085/jgp.200910320 |