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Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1
Polyamine block of inwardly rectifying potassium (Kir) channels underlies their steep voltage dependence observed in vivo. We have examined the potency, voltage dependence, and kinetics of spermine block in dimeric Kir2.1 constructs containing one nonreactive subunit and one cysteine-substituted sub...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860589/ https://www.ncbi.nlm.nih.gov/pubmed/20421374 http://dx.doi.org/10.1085/jgp.200910253 |