Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of I(Ks)

Long QT interval syndrome (LQTS) type 1 (LQT1) has been reported to arise from mutations in the S3 domain of KCNQ1, but none of the seven S3 mutations in the literature have been characterized with respect to trafficking or biophysical deficiencies. Surface channel expression was studied using a pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Eldstrom, Jodene, Xu, Hongjian, Werry, Daniel, Kang, Congbao, Loewen, Matthew E., Degenhardt, Amanda, Sanatani, Shubhayan, Tibbits, Glen F., Sanders, Charles, Fedida, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860592/
https://www.ncbi.nlm.nih.gov/pubmed/20421371
http://dx.doi.org/10.1085/jgp.200910351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860592/
https://www.ncbi.nlm.nih.gov/pubmed/20421371
http://dx.doi.org/10.1085/jgp.200910351

Ejemplares similares