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Glycine(311), a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix
The tremorogenic fungal metabolite, paxilline, is widely used as a potent and relatively specific blocker of Ca(2+)- and voltage-activated Slo1 (or BK) K(+) channels. The pH-regulated Slo3 K(+) channel, a Slo1 homologue, is resistant to blockade by paxilline. Taking advantage of the marked differenc...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860595/ https://www.ncbi.nlm.nih.gov/pubmed/20421373 http://dx.doi.org/10.1085/jgp.201010403 |