CARGO RECOGNITION FAILURE IS RESPONSIBLE FOR INEFFICIENT AUTOPHAGY IN HUNTINGTON’S DISEASE

Continuous turnover of intracellular components by autophagy is necessary to preserve cellular homeostasis in all tissues. Alterations in macroautophagy, main responsible for bulk autophagic degradation, have been proposed to contribute to pathogenesis in Huntington’s disease (HD), a genetic neurode...

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Detalles Bibliográficos
Autores principales: Martinez–Vicente, M, Talloczy, Z, Wong, E, Tang, G, Koga, H, Kaushik, S, de Vries, R, Arias, E, Harris, S, Sulzer, D, Cuervo, AM
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860687/
https://www.ncbi.nlm.nih.gov/pubmed/20383138
http://dx.doi.org/10.1038/nn.2528

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