Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by transient ischaemia; this is believed to reflect inh...

Descripción completa

Detalles Bibliográficos
Autores principales: Malouitre, Sylvanie, Dube, Henry, Selwood, David, Crompton, Martin
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860807/
https://www.ncbi.nlm.nih.gov/pubmed/19832699
http://dx.doi.org/10.1042/BJ20090332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860807/
https://www.ncbi.nlm.nih.gov/pubmed/19832699
http://dx.doi.org/10.1042/BJ20090332

Ejemplares similares