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Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by transient ischaemia; this is believed to reflect inh...

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Detalles Bibliográficos
Autores principales:	Malouitre, Sylvanie, Dube, Henry, Selwood, David, Crompton, Martin
Formato:	Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860807/ https://www.ncbi.nlm.nih.gov/pubmed/19832699 http://dx.doi.org/10.1042/BJ20090332

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