Cargando…

Doxorubicin in Combination with a Small TGFβ Inhibitor: A Potential Novel Therapy for Metastatic Breast Cancer in Mouse Models

BACKGROUND: Recent studies suggested that induction of epithelial-mesenchymal transition (EMT) might confer both metastatic and self-renewal properties to breast tumor cells resulting in drug resistance and tumor recurrence. TGFβ is a potent inducer of EMT and has been shown to promote tumor progres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bandyopadhyay, Abhik, Wang, Long, Agyin, Joseph, Tang, Yuping, Lin, Shu, Yeh, I-Tien, De, Keya, Sun, Lu-Zhe
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860989/ https://www.ncbi.nlm.nih.gov/pubmed/20442777 http://dx.doi.org/10.1371/journal.pone.0010365

Ejemplares similares

Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells
por: Lin, Shu, et al.
Publicado: (2012)

Isolation and Characterization of a Metastatic Hybrid Cell Line Generated by ER Negative and ER Positive Breast Cancer Cells in Mouse Bone Marrow
por: Mukhopadhyay, Keya De, et al.
Publicado: (2011)

Doxorubicin-Induced Modulation of TGF-β Signaling Cascade in Mouse Fibroblasts: Insights into Cardiotoxicity Mechanisms
por: Patricelli, Conner, et al.
Publicado: (2023)

Doxorubicin-induced modulation of TGF-β signaling cascade in mouse fibroblasts: insights into cardiotoxicity mechanisms
por: Patricelli, Conner, et al.
Publicado: (2023)

PSPC1 potentiates TGF-β-dependent metastatic dissemination
por: Yeh, Hsi-Wen, et al.
Publicado: (2018)

An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model
por: Oshiro, Hiromichi, et al.
Publicado: (2021)

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
por: Blum, Barak, et al.
Publicado: (2014)

Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway
por: Ren, Xianguo, et al.
Publicado: (2016)

Aromatase Expression Increases the Survival and Malignancy of Estrogen Receptor Positive Breast Cancer Cells
por: Mukhopadhyay, Keya De, et al.
Publicado: (2015)

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage
por: Wang, Weiguang, et al.
Publicado: (2019)

TGF-β-Induced TMEPAI Attenuates the Response of Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel
por: Wardhani, Bantari WK, et al.
Publicado: (2020)

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
por: Holmgaard, Rikke B., et al.
Publicado: (2018)

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium
por: Flanders, Kathleen C., et al.
Publicado: (2016)

The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing α(v)β(3) integrin in chick embryo and nude mouse models
por: Tome, Yasunori, et al.
Publicado: (2016)

Advances in Immunotherapy and the TGF-β Resistance Pathway in Metastatic Bladder Cancer
por: Benjamin, David J., et al.
Publicado: (2021)

TGF-β Inhibitors for Therapeutic Management of Kidney Fibrosis
por: Park, Cheol Ho, et al.
Publicado: (2022)

Combination of Polymeric Micelle Formulation of TGFβ Receptor Inhibitors and Paclitaxel Produce Consistent Response Across Different Mouse Models of TNBC
por: Vinod, Natasha, et al.
Publicado: (2023)

TGFβ signaling supports survival and metastasis of endometrial cancer cells
por: Lei, XiuFen, et al.
Publicado: (2009)

Combined targeting of TGF-β1 and integrin β3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer
por: Salvo, Elizabeth, et al.
Publicado: (2014)

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy
por: van Kuijk, Simon J. A., et al.
Publicado: (2016)

Repression of Smad4 by MicroRNA-1285 moderates TGF-β-induced epithelial–mesenchymal transition in proliferative vitreoretinopathy
por: Pao, Shu-I, et al.
Publicado: (2021)

Vernonia amygdalina Ethanol Extract Protects against Doxorubicin-Induced Cardiotoxicity via TGFβ, Cytochrome c, and Apoptosis
por: Syahputra, Rony Abdi, et al.
Publicado: (2023)

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide
por: Chen, Xin, et al.
Publicado: (2014)

A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment
por: Huynh, Linh Khanh, et al.
Publicado: (2019)

Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGFβR Regulating TGF-β/Smad Pathway
por: Du, Haiyan, et al.
Publicado: (2021)

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II
por: Dituri, Francesco, et al.
Publicado: (2013)

Improved efficacy of radiation in combination with TGFβ inhibition in a colorectal cancer mouse model
por: Young, Kristina H, et al.
Publicado: (2013)

DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets
por: Pucelik, Barbara, et al.
Publicado: (2023)

Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin
por: Wong, John, et al.
Publicado: (2013)

HSP-90 Inhibitor Ganetespib is Synergistic with Doxorubicin in Small Cell Lung Cancer
por: Lai, Chien-Hao, et al.
Publicado: (2013)

AR12286 Alleviates TGF-β-Related Myofibroblast Transdifferentiation and Reduces Fibrosis after Glaucoma Filtration Surgery
por: Cheng, Wen-Sheng, et al.
Publicado: (2020)

Doxorubicin-Mediated Bone Loss in Breast Cancer Bone Metastases Is Driven by an Interplay between Oxidative Stress and Induction of TGFβ
por: Rana, Tapasi, et al.
Publicado: (2013)

Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors
por: Hong, Eunji, et al.
Publicado: (2023)

Pentabromopseudilin: a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation
por: Shih-Wei, Wang, et al.
Publicado: (2018)

TGF-β receptor inhibitor LY2109761 enhances the radiosensitivity of gastric cancer by inactivating the TGF-β/SMAD4 signaling pathway
por: Yang, Tian, et al.
Publicado: (2019)

RepSox, a small molecule inhibitor of the TGFβ receptor, induces brown adipogenesis and browning of white adipocytes
por: Tu, Wan-zhi, et al.
Publicado: (2019)

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
por: Slattery, Karen, et al.
Publicado: (2021)

Correction: Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II
Publicado: (2014)

Correction: Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II
por: Dituri, Francesco, et al.
Publicado: (2013)

Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung
por: Sureshbabu, Angara, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_k554el0smp52ku7020jtnuosdv