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Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study

BACKGROUND: Epidermal growth factor receptor inhibitors are widely prescribed anticancer drugs. Patients treated commonly develop dermatologic adverse drugs reactions, but rarely they are involved in systematic evaluation of their quality of life. This monocentric cross sectional study is carried ou...

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Autores principales: Andreis, Federica, Rizzi, Anna, Mosconi, Paola, Braun, Claudia, Rota, Luigina, Meriggi, Fausto, Mazzocchi, Maria, Zaniboni, Alberto
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861022/
https://www.ncbi.nlm.nih.gov/pubmed/20398332
http://dx.doi.org/10.1186/1477-7525-8-40
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author Andreis, Federica
Rizzi, Anna
Mosconi, Paola
Braun, Claudia
Rota, Luigina
Meriggi, Fausto
Mazzocchi, Maria
Zaniboni, Alberto
author_facet Andreis, Federica
Rizzi, Anna
Mosconi, Paola
Braun, Claudia
Rota, Luigina
Meriggi, Fausto
Mazzocchi, Maria
Zaniboni, Alberto
author_sort Andreis, Federica
collection PubMed
description BACKGROUND: Epidermal growth factor receptor inhibitors are widely prescribed anticancer drugs. Patients treated commonly develop dermatologic adverse drugs reactions, but rarely they are involved in systematic evaluation of their quality of life. This monocentric cross sectional study is carried out to assess quality of life in colon cancer patients experienced skin side effects due to anti epidermal growth factor receptor inhibitors therapy. METHODS: Consecutive patients with skin side effects to therapy treated at Fondazione Poliambulanza were enrolled in this study. Quality of life was evaluated with the Italian validated version of Skindex-29 questionnaire, exploring three dimensions: symptoms, emotional, and physical functioning. Skindex-29 was administered one time between the eighth and the twelfth week of the treatment. RESULTS: Forty-five consecutive patients, mainly with metastatic colon cancer (29 female, 16 male), with an average age of 59.31 years (ranging from 34-78) were included in the study and analyzed. Patients showed a great impact of skin side effects on symptoms (mean 43), followed by emotional (mean 30), and functioning (mean 26) scales. In general women, the 55-65 age class, and patients with partial remission reported the worst quality of life. CONCLUSIONS: Epidermal growth factor receptor inhibitors' skin side effects have an important impact on quality of life in advanced colon cancer patients; symptoms scale is the most effect respect to emotional and functioning scales.
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spelling pubmed-28610222010-04-29 Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study Andreis, Federica Rizzi, Anna Mosconi, Paola Braun, Claudia Rota, Luigina Meriggi, Fausto Mazzocchi, Maria Zaniboni, Alberto Health Qual Life Outcomes Research BACKGROUND: Epidermal growth factor receptor inhibitors are widely prescribed anticancer drugs. Patients treated commonly develop dermatologic adverse drugs reactions, but rarely they are involved in systematic evaluation of their quality of life. This monocentric cross sectional study is carried out to assess quality of life in colon cancer patients experienced skin side effects due to anti epidermal growth factor receptor inhibitors therapy. METHODS: Consecutive patients with skin side effects to therapy treated at Fondazione Poliambulanza were enrolled in this study. Quality of life was evaluated with the Italian validated version of Skindex-29 questionnaire, exploring three dimensions: symptoms, emotional, and physical functioning. Skindex-29 was administered one time between the eighth and the twelfth week of the treatment. RESULTS: Forty-five consecutive patients, mainly with metastatic colon cancer (29 female, 16 male), with an average age of 59.31 years (ranging from 34-78) were included in the study and analyzed. Patients showed a great impact of skin side effects on symptoms (mean 43), followed by emotional (mean 30), and functioning (mean 26) scales. In general women, the 55-65 age class, and patients with partial remission reported the worst quality of life. CONCLUSIONS: Epidermal growth factor receptor inhibitors' skin side effects have an important impact on quality of life in advanced colon cancer patients; symptoms scale is the most effect respect to emotional and functioning scales. BioMed Central 2010-04-15 /pmc/articles/PMC2861022/ /pubmed/20398332 http://dx.doi.org/10.1186/1477-7525-8-40 Text en Copyright ©2010 Andreis et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Andreis, Federica
Rizzi, Anna
Mosconi, Paola
Braun, Claudia
Rota, Luigina
Meriggi, Fausto
Mazzocchi, Maria
Zaniboni, Alberto
Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
title Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
title_full Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
title_fullStr Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
title_full_unstemmed Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
title_short Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
title_sort quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861022/
https://www.ncbi.nlm.nih.gov/pubmed/20398332
http://dx.doi.org/10.1186/1477-7525-8-40
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