Generation of stable monoclonal antibody-producing BCR(+) human memory B cells by genetic programming

B cell lymphoma (BCL)6 and Bcl-xL are expressed in germinal center (GC) B cells and enable them to endure the proliferative and mutagenic environment of the GC. By introducing these genes into peripheral blood memory B cells and culturing these cells with factors produced by follicular helper T cell...

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Detalles Bibliográficos
Autores principales: Kwakkenbos, Mark J., Diehl, Sean A., Yasuda, Etsuko, Bakker, Arjen Q., van Geelen, Caroline M.M., Lukens, Michaël V., van Bleek, Grada M., Widjojoatmodjo, Myra N., Bogers, Willy M.J.M., Mei, Henrik, Radbruch, Andreas, Scheeren, Ferenc A., Spits, Hergen, Beaumont, Tim
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861345/
https://www.ncbi.nlm.nih.gov/pubmed/20023635
http://dx.doi.org/10.1038/nm.2071

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