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Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision

Language barrier, race, immigration status, mental health illness, substance abuse and socioeconomic status are often not considered when evaluating hepatitis C virus (HCV) sustained virological response (SVR) in human immunodeficiency virus (HIV) infection. The influence of these factors on HCV wor...

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Autores principales: Cooper, Curtis L, Giordano, Celine, Mackie, Dave, Mills, Edward J
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861442/
https://www.ncbi.nlm.nih.gov/pubmed/20463782
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author Cooper, Curtis L
Giordano, Celine
Mackie, Dave
Mills, Edward J
author_facet Cooper, Curtis L
Giordano, Celine
Mackie, Dave
Mills, Edward J
author_sort Cooper, Curtis L
collection PubMed
description Language barrier, race, immigration status, mental health illness, substance abuse and socioeconomic status are often not considered when evaluating hepatitis C virus (HCV) sustained virological response (SVR) in human immunodeficiency virus (HIV) infection. The influence of these factors on HCV work-up, treatment initiation and SVR were assessed in an HIV–HCV coinfected population and compared to patients with HCV mono-infection. The setting was a publicly funded, urban-based, multidisciplinary viral hepatitis clinic. A clinical database was utilized to identify HIV and HCV consults between June 2000 and June 2007. Measures of access to HCV care (ie, liver biopsy and HCV antiviral initiation) and SVR as a function of the above variables were evaluated and compared between patients with HIV–HCV and HCV. HIV–HCV co-infected (n = 106) and HCV mono-infected (n = 802) patients were evaluated. HIV–HCV patients were more often white (94% versus 84%) and male (87% versus 69%). Bridging fibrosis or cirrhosis on biopsy was more frequent in HIV–HCV (37% versus 22%; P = 0.03). HIV infection itself did not influence access to biopsy (50% versus 52%) or treatment initiation (39% versus 38%). Race, language barrier, immigration status, injection drug history and socioeconomic status did not influence access to biopsy or treatment. SVR was 54% in HCV and 30% in HIV–HCV (P = 0.003). Genotype and HIV were the only evaluated variables to predict SVR. Within the context of a socialized, multidisciplinary clinic, HIV–HCV co-infected patients received similar access to HCV work-up and care as HCV mono-infected patients. SVR is diminished in HIV–HCV co-infection independent of language barrier, race, immigration status, or socioeconomic status.
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spelling pubmed-28614422010-05-12 Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision Cooper, Curtis L Giordano, Celine Mackie, Dave Mills, Edward J Ther Clin Risk Manag Original Research Language barrier, race, immigration status, mental health illness, substance abuse and socioeconomic status are often not considered when evaluating hepatitis C virus (HCV) sustained virological response (SVR) in human immunodeficiency virus (HIV) infection. The influence of these factors on HCV work-up, treatment initiation and SVR were assessed in an HIV–HCV coinfected population and compared to patients with HCV mono-infection. The setting was a publicly funded, urban-based, multidisciplinary viral hepatitis clinic. A clinical database was utilized to identify HIV and HCV consults between June 2000 and June 2007. Measures of access to HCV care (ie, liver biopsy and HCV antiviral initiation) and SVR as a function of the above variables were evaluated and compared between patients with HIV–HCV and HCV. HIV–HCV co-infected (n = 106) and HCV mono-infected (n = 802) patients were evaluated. HIV–HCV patients were more often white (94% versus 84%) and male (87% versus 69%). Bridging fibrosis or cirrhosis on biopsy was more frequent in HIV–HCV (37% versus 22%; P = 0.03). HIV infection itself did not influence access to biopsy (50% versus 52%) or treatment initiation (39% versus 38%). Race, language barrier, immigration status, injection drug history and socioeconomic status did not influence access to biopsy or treatment. SVR was 54% in HCV and 30% in HIV–HCV (P = 0.003). Genotype and HIV were the only evaluated variables to predict SVR. Within the context of a socialized, multidisciplinary clinic, HIV–HCV co-infected patients received similar access to HCV work-up and care as HCV mono-infected patients. SVR is diminished in HIV–HCV co-infection independent of language barrier, race, immigration status, or socioeconomic status. Dove Medical Press 2010 2010-04-26 /pmc/articles/PMC2861442/ /pubmed/20463782 Text en © 2010 Cooper et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Cooper, Curtis L
Giordano, Celine
Mackie, Dave
Mills, Edward J
Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision
title Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision
title_full Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision
title_fullStr Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision
title_full_unstemmed Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision
title_short Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision
title_sort equitable access to hcv care in hiv-hcv co-infection can be achieved despite barriers to health care provision
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861442/
https://www.ncbi.nlm.nih.gov/pubmed/20463782
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